The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. elegans

• Published in: eLife Vol. 7
• Main Authors: Davis, Gregory M, Tu, Shikui, Anderson, Joshua WT, Colson, Rhys N, Gunzburg, Menachem J, Francisco, Michelle A, Ray, Debashish, Shrubsole, Sean P, Sobotka, Julia A, Seroussi, Uri, Lao, Robert X, Maity, Tuhin, Wu, Monica Z, McJunkin, Katherine, Morris, Quaid D, Hughes, Timothy R, Wilce, Jacqueline A, Claycomb, Julie M, Weng, Zhiping, Boag, Peter R
• Format: Journal Article
• Language: English
• Published: Cambridge eLife Sciences Publications Ltd 21.12.2018; eLife Sciences Publications, Ltd
• Subjects: 22G RNAs; Biology; Biosynthesis; Caenorhabditis elegans; Chromatin; Chromosomes and Gene Expression; Gene expression; Genetics and Genomics; Genomes; Homeostasis; Meiosis; Proteins; Ribonucleic acid; RNA; RNA polymerase; RNA-binding protein; RNA-mediated interference; RNAi; small RNAs; TRIM-NHL; Australia; United States > US

Proper regulation of germline gene expression is essential for fertility and maintaining species integrity. In the C. elegans germline, a diverse repertoire of regulatory pathways promote the expression of endogenous germline genes and limit the expression of deleterious transcripts to maintain geno...