Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice

• Published in: Life sciences (1973) Vol. 217; pp. 8 - 15
• Main Authors: Zhang, Wen-xuan, He, Bai-mei, Wu, Ying, Qiao, Jian-feng, Peng, Zhen-yu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.01.2019
• Subjects: Animals; Apoptosis; Apoptosis - drug effects; Autophagy; Autophagy - drug effects; biomarkers; Cardiac dysfunction; cardiac output; cardiomyocytes; cardioprotective effect; Cardiotonic Agents - therapeutic use; caspase-3; creatine kinase; Heart - drug effects; Heart - physiopathology; Heart Diseases - etiology; Heart Diseases - metabolism; Heart Diseases - physiopathology; Heart Diseases - prevention & control; histopathology; lipopolysaccharides; Male; males; Melatonin; Melatonin - therapeutic use; mice; Mice, Inbred C57BL; Myocardium - metabolism; Myocardium - pathology; pathogenesis; protein synthesis; Sepsis; sepsis (infection); Sepsis - complications; Sepsis - metabolism; Sepsis - physiopathology; SIRT1; Sirtuin 1 - analysis; Sirtuin 1 - metabolism; therapeutics; Sepsis; Melatonin; Autophagy; SIRT1; Cardiac dysfunction; Apoptosis

The apoptosis and autophagy play an important role in the pathogenesis of sepsis-induced cardiac dysfunction. Previous studies have demonstrated that melatonin protects against cardiac dysfunction during sepsis. In addition, silent information regulator 1 (SIRT1) is a therapeutic target for sepsis-i...