Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice - Zhang, Wen-xuan; He, Bai-mei; Wu, Ying; Qiao, Jian-feng; Peng, Zhen-yu (Life sciences (1973), 2019)
Keywords: Animals; Apoptosis; Apoptosis - drug effects; Autophagy; Autophagy - drug effects; biomarkers; Cardiac dysfunction; cardiac output; cardiomyocytes; cardioprotective effect; Cardiotonic Agents - therapeutic use; caspase-3; creatine kinase; Heart - drug effects; Heart - physiopathology; Heart Diseases - etiology; Heart Diseases - metabolism; Heart Diseases - physiopathology; Heart Diseases - prevention & control; histopathology; lipopolysaccharides; Male; males; Melatonin; Melatonin - therapeutic use; mice; Mice, Inbred C57BL; Myocardium - metabolism; Myocardium - pathology; pathogenesis; protein synthesis; Sepsis; sepsis (infection); Sepsis - complications; Sepsis - metabolism; Sepsis - physiopathology; SIRT1; Sirtuin 1 - analysis; Sirtuin 1 - metabolism; therapeutics; Sepsis; Melatonin; Autophagy; SIRT1; Cardiac dysfunction; Apoptosis