Multifunctional Antibodies Are Induced by the RTS,S Malaria Vaccine and Associated With Protection in a Phase 1/2a Trial

• Published in: The Journal of infectious diseases Vol. 224; no. 7; pp. 1128 - 1138
• Main Authors: Kurtovic, Liriye, Atre, Tanmaya, Feng, Gaoqian, Wines, Bruce D, Chan, Jo-Anne, Boyle, Michelle J, Drew, Damien R, Hogarth, P Mark, Fowkes, Freya J I, Bergmann-Leitner, Elke S, Beeson, James G
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 13.10.2021
• Subjects: Antibodies; Antibodies, Protozoan - blood; Antigens, Protozoan; Circumsporozoite protein; Clinical trials; Humans; Immunoglobulin M; Major and Brief Reports; Malaria; Malaria - blood; Malaria - prevention & control; Malaria Vaccines - administration & dosage; Malaria Vaccines - immunology; Parasitemia; Plasmodium falciparum; Protozoan Proteins; Vaccine Efficacy; Vaccines; circumsporozoite protein; opsonic phagocytosis; vaccines; antibodies; Fcγ-receptor; complement; malaria; Plasmodium falciparum

Abstract Background RTS,S is the leading malaria vaccine candidate but only confers partial efficacy against malaria in children. RTS,S is based on the major Plasmodium falciparum sporozoite surface antigen, circumsporozoite protein (CSP). The induction of anti-CSP antibodies is important for protec...