50 Years of the steric-blocking mechanism in vertebrate skeletal muscle: a retrospective

• Published in: Journal of muscle research and cell motility Vol. 44; no. 3; pp. 133 - 141
• Main Author: Parry, David A. D.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.09.2023; Springer Nature B.V
• Subjects: Animal Anatomy; Biomedical and Life Sciences; Biomedicine; Cell Biology; Histology; Life Sciences; Morphology; Motility; Muscle contraction; Musculoskeletal system; Physics; Proteomics; Review; Skeletal muscle; Tropomyosin; Troponin; Zoology; Troponin; Tropomyosin; Actin; X-ray diffraction; Relaxed and contracting muscle; HMM S-1; 3-D reconstruction

Fifty years have now passed since Parry and Squire proposed a detailed structural model that explained how tropomyosin, mediated by troponin, played a steric-blocking role in the regulation of vertebrate skeletal muscle. In this Special Issue dedicated to the memory of John Squire it is an opportune...