50 Years of the steric-blocking mechanism in vertebrate skeletal muscle: a retrospective
Fifty years have now passed since Parry and Squire proposed a detailed structural model that explained how tropomyosin, mediated by troponin, played a steric-blocking role in the regulation of vertebrate skeletal muscle. In this Special Issue dedicated to the memory of John Squire it is an opportune...
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Published in | Journal of muscle research and cell motility Vol. 44; no. 3; pp. 133 - 141 |
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Format | Journal Article |
Language | English |
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Springer International Publishing
01.09.2023
Springer Nature B.V |
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Abstract | Fifty years have now passed since Parry and Squire proposed a detailed structural model that explained how tropomyosin, mediated by troponin, played a steric-blocking role in the regulation of vertebrate skeletal muscle. In this Special Issue dedicated to the memory of John Squire it is an opportune time to look back on this research and to appreciate John’s key contributions. A review is also presented of a selection of the developments and insights into muscle regulation that have occurred in the years since this proposal was formulated. |
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AbstractList | Fifty years have now passed since Parry and Squire proposed a detailed structural model that explained how tropomyosin, mediated by troponin, played a steric-blocking role in the regulation of vertebrate skeletal muscle. In this Special Issue dedicated to the memory of John Squire it is an opportune time to look back on this research and to appreciate John’s key contributions. A review is also presented of a selection of the developments and insights into muscle regulation that have occurred in the years since this proposal was formulated. |
Author | Parry, David A. D. |
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Keywords | Troponin Tropomyosin Actin X-ray diffraction Relaxed and contracting muscle HMM S-1 3-D reconstruction |
Language | English |
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SubjectTerms | Animal Anatomy Biomedical and Life Sciences Biomedicine Cell Biology Histology Life Sciences Morphology Motility Muscle contraction Musculoskeletal system Physics Proteomics Review Skeletal muscle Tropomyosin Troponin Zoology |
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Title | 50 Years of the steric-blocking mechanism in vertebrate skeletal muscle: a retrospective |
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