Human DJ-1 and its homologs are novel glyoxalases

• Published in: Human molecular genetics Vol. 21; no. 14; pp. 3215 - 3225
• Main Authors: LEE, Ju-Young, SONG, Jeeyeon, KWON, Kyu, SUMI JANG, KIM, Chayeon, BAEK, Kwanghee, KIM, Jeongho, PARK, Chankyu
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.07.2012
• Subjects: Age; Aldehyde Oxidoreductases - chemistry; Aldehyde Oxidoreductases - genetics; Aldehyde Oxidoreductases - metabolism; Amino Acid Sequence; Animals; Apoptosis; Biological and medical sciences; Caenorhabditis elegans; Caenorhabditis elegans - chemistry; Caenorhabditis elegans - enzymology; Caenorhabditis elegans - genetics; Caenorhabditis elegans Proteins - chemistry; Caenorhabditis elegans Proteins - genetics; Caenorhabditis elegans Proteins - metabolism; carbonyls; Cell Line; Cell physiology; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Cysteine; Dopamine; Embryo fibroblasts; Fundamental and applied biological sciences. Psychology; Genetics of eukaryotes. Biological and molecular evolution; Glutamic acid; Glutathione; Glyoxal - metabolism; Humans; Intestine; Intracellular Signaling Peptides and Proteins - chemistry; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Kinetics; Lactic acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular and cellular biology; Molecular Sequence Data; Movement disorders; Neurodegeneration; Neurodegenerative diseases; Neurons; Neurons - cytology; Neurons - enzymology; Neurons - metabolism; Oncogene Proteins - chemistry; Oncogene Proteins - genetics; Oncogene Proteins - metabolism; PARK7 protein; Parkinson Disease - enzymology; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson's disease; Peroxiredoxins; Protein Deglycase DJ-1; Pyruvaldehyde; Pyruvaldehyde - metabolism; Rats; Sequence Alignment; Human; Genetics; C-Onc gene; Protooncogene

Human DJ-1 is a genetic cause of early-onset Parkinson's disease (PD), although its biochemical function is unknown. We report here that human DJ-1 and its homologs of the mouse and Caenorhabditis elegans are novel types of glyoxalase, converting glyoxal or methylglyoxal to glycolic or lactic a...