Human DJ-1 and its homologs are novel glyoxalases
Human DJ-1 is a genetic cause of early-onset Parkinson's disease (PD), although its biochemical function is unknown. We report here that human DJ-1 and its homologs of the mouse and Caenorhabditis elegans are novel types of glyoxalase, converting glyoxal or methylglyoxal to glycolic or lactic a...
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Published in | Human molecular genetics Vol. 21; no. 14; pp. 3215 - 3225 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Oxford University Press
15.07.2012
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Abstract | Human DJ-1 is a genetic cause of early-onset Parkinson's disease (PD), although its biochemical function is unknown. We report here that human DJ-1 and its homologs of the mouse and Caenorhabditis elegans are novel types of glyoxalase, converting glyoxal or methylglyoxal to glycolic or lactic acid, respectively, in the absence of glutathione. Purified DJ-1 proteins exhibit typical Michaelis-Menten kinetics, which were abolished completely in the mutants of essential catalytic residues, consisting of cysteine and glutamic acid. The presence of DJ-1 protected mouse embryonic fibroblast and dopaminergically derived SH-SY5Y cells from treatments of glyoxals. Likewise, C. elegans lacking cDJR-1.1, a DJ-1 homolog expressed primarily in the intestine, protected worms from glyoxal-induced death. Sub-lethal doses of glyoxals caused significant degeneration of the dopaminergic neurons in C. elegans lacking cDJR-1.2, another DJ-1 homolog expressed primarily in the head region, including neurons. Our findings that DJ-1 serves as scavengers for reactive carbonyl species may provide a new insight into the causation of PD. |
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AbstractList | Human DJ-1 is a genetic cause of early-onset Parkinson's disease (PD), although its biochemical function is unknown. We report here that human DJ-1 and its homologs of the mouse and Caenorhabditis elegans are novel types of glyoxalase, converting glyoxal or methylglyoxal to glycolic or lactic acid, respectively, in the absence of glutathione. Purified DJ-1 proteins exhibit typical Michaelis-Menten kinetics, which were abolished completely in the mutants of essential catalytic residues, consisting of cysteine and glutamic acid. The presence of DJ-1 protected mouse embryonic fibroblast and dopaminergically derived SH-SY5Y cells from treatments of glyoxals. Likewise, C. elegans lacking cDJR-1.1, a DJ-1 homolog expressed primarily in the intestine, protected worms from glyoxal-induced death. Sub-lethal doses of glyoxals caused significant degeneration of the dopaminergic neurons in C. elegans lacking cDJR-1.2, another DJ-1 homolog expressed primarily in the head region, including neurons. Our findings that DJ-1 serves as scavengers for reactive carbonyl species may provide a new insight into the causation of PD. |
Author | BAEK, Kwanghee PARK, Chankyu SUMI JANG KIM, Jeongho LEE, Ju-Young KWON, Kyu SONG, Jeeyeon KIM, Chayeon |
Author_xml | – sequence: 1 givenname: Ju-Young surname: LEE fullname: LEE, Ju-Young organization: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon 305-701, Korea, Republic of – sequence: 2 givenname: Jeeyeon surname: SONG fullname: SONG, Jeeyeon organization: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon 305-701, Korea, Republic of – sequence: 3 givenname: Kyu surname: KWON fullname: KWON, Kyu organization: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon 305-701, Korea, Republic of – sequence: 4 surname: SUMI JANG fullname: SUMI JANG organization: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon 305-701, Korea, Republic of – sequence: 5 givenname: Chayeon surname: KIM fullname: KIM, Chayeon organization: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon 305-701, Korea, Republic of – sequence: 6 givenname: Kwanghee surname: BAEK fullname: BAEK, Kwanghee organization: Department of Genetic Engineering and Graduate School of Biotechnology, Kyung Hee University, Yongin 446-701, Korea, Republic of – sequence: 7 givenname: Jeongho surname: KIM fullname: KIM, Jeongho organization: Department of Biological Sciences, Inha University, Incheon 402-751, Korea, Republic of – sequence: 8 givenname: Chankyu surname: PARK fullname: PARK, Chankyu organization: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon 305-701, Korea, Republic of |
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Cites_doi | 10.1126/science.1077209 10.1111/j.1601-183X.2009.00559.x 10.1371/journal.pbio.0020362 10.1093/brain/awh054 10.1002/(SICI)1097-4547(19990715)57:2<280::AID-JNR14>3.0.CO;2-U 10.1093/hmg/ddi211 10.1074/jbc.M507124200 10.1073/pnas.0607260103 10.1006/bbrc.1999.0221 10.1016/j.bcp.2004.06.013 10.1111/j.1365-2958.2011.07736.x 10.1016/j.freeradbiomed.2009.08.003 10.1038/nature09536 10.1016/j.nbd.2006.06.004 10.1042/bj2690001 10.1073/pnas.042497999 10.1093/hmg/ddq430 10.1042/bj3050999 10.1073/pnas.0911175107 10.1016/S0021-9258(18)42844-X 10.1016/j.cub.2005.07.064 10.1016/j.jmb.2005.08.033 10.1371/journal.pbio.0020327 10.1093/hmg/ddq288 10.1042/BST0361045 10.1074/jbc.M804243200 10.1093/cercor/bhh123 10.1016/j.neurobiolaging.2006.05.007 10.1002/dvdy.22231 10.1111/j.1474-9726.2008.00371.x 10.1016/S0891-0618(00)00096-X 10.1006/bbrc.1997.6132 10.1038/sj.embor.7400074 10.1093/genetics/77.1.71 10.1074/jbc.M505910200 10.1146/annurev.med.46.1.223 10.1042/BJ20111648 10.1073/pnas.0402959101 10.1042/bj3440109 10.1007/s00018-010-0483-7 10.4161/oxim.2.1.7985 |
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References | Inden ( key 20170522124519_DDS155C30) 2006; 24 Bandopadhyay ( key 20170522124519_DDS155C25) 2004; 127 Shangari ( key 20170522124519_DDS155C29) 2004; 68 Thornalley ( key 20170522124519_DDS155C15) 1990; 269 Subedi ( key 20170522124519_DDS155C18) 2011; 81 Brownlee ( key 20170522124519_DDS155C12) 1995; 46 Harrington ( key 20170522124519_DDS155C9) 2010; 239 Shendelman ( key 20170522124519_DDS155C36) 2004; 2 Clements ( key 20170522124519_DDS155C23) 2006; 103 Irrcher ( key 20170522124519_DDS155C39) 2010; 19 Kikuchi ( key 20170522124519_DDS155C14) 1999; 57 Morcos ( key 20170522124519_DDS155C27) 2008; 7 Martinat ( key 20170522124519_DDS155C7) 2004; 2 Pham ( key 20170522124519_DDS155C34) 2010; 9 Guzman ( key 20170522124519_DDS155C4) 2010; 468 Thornalley ( key 20170522124519_DDS155C10) 1999; 344 Wilson ( key 20170522124519_DDS155C32) 2005; 353 Rabbani ( key 20170522124519_DDS155C38) 2008; 36 Misra ( key 20170522124519_DDS155C17) 1995; 305 Canet-Aviles ( key 20170522124519_DDS155C3) 2004; 101 Zhou ( key 20170522124519_DDS155C31) 2005; 280 de Arriba ( key 20170522124519_DDS155C37) 2007; 28 Kahle ( key 20170522124519_DDS155C35) 2009; 47 Nagakubo ( key 20170522124519_DDS155C2) 1997; 231 Kurz ( key 20170522124519_DDS155C21) 2011; 68 Xue ( key 20170522124519_DDS155C22) 2012; 443 Meulener ( key 20170522124519_DDS155C5) 2005; 15 Ved ( key 20170522124519_DDS155C8) 2005; 280 Taira ( key 20170522124519_DDS155C6) 2004; 5 Hao ( key 20170522124519_DDS155C41) 2010; 107 Thomas ( key 20170522124519_DDS155C40) 2011; 20 Odani ( key 20170522124519_DDS155C20) 1999; 256 Luth ( key 20170522124519_DDS155C13) 2005; 15 Vander Jagt ( key 20170522124519_DDS155C16) 1992; 267 Cha ( key 20170522124519_DDS155C19) 2008; 283 Nass ( key 20170522124519_DDS155C28) 2002; 99 Munch ( key 20170522124519_DDS155C11) 2000; 20 Niki ( key 20170522124519_DDS155C24) 2003; 1 Bonifati ( key 20170522124519_DDS155C1) 2003; 299 Zhang ( key 20170522124519_DDS155C26) 2005; 14 Yanagida ( key 20170522124519_DDS155C33) 2009; 2 Brenner ( key 20170522124519_DDS155C42) 1974; 77 |
References_xml | – volume: 299 start-page: 256 year: 2003 ident: key 20170522124519_DDS155C1 article-title: Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism publication-title: Science doi: 10.1126/science.1077209 contributor: fullname: Bonifati – volume: 9 start-page: 305 year: 2010 ident: key 20170522124519_DDS155C34 article-title: DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments publication-title: Genes Brain Behav. doi: 10.1111/j.1601-183X.2009.00559.x contributor: fullname: Pham – volume: 2 start-page: e362 year: 2004 ident: key 20170522124519_DDS155C36 article-title: DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0020362 contributor: fullname: Shendelman – volume: 127 start-page: 420 year: 2004 ident: key 20170522124519_DDS155C25 article-title: The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease publication-title: Brain doi: 10.1093/brain/awh054 contributor: fullname: Bandopadhyay – volume: 57 start-page: 280 year: 1999 ident: key 20170522124519_DDS155C14 article-title: Neurotoxicity of methylglyoxal and 3-deoxyglucosone on cultured cortical neurons: synergism between glycation and oxidative stress, possibly involved in neurodegenerative diseases publication-title: J. Neurosci. Res. doi: 10.1002/(SICI)1097-4547(19990715)57:2<280::AID-JNR14>3.0.CO;2-U contributor: fullname: Kikuchi – volume: 14 start-page: 2063 year: 2005 ident: key 20170522124519_DDS155C26 article-title: Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddi211 contributor: fullname: Zhang – volume: 280 start-page: 43150 year: 2005 ident: key 20170522124519_DDS155C31 article-title: DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity publication-title: J. Biol. Chem. doi: 10.1074/jbc.M507124200 contributor: fullname: Zhou – volume: 103 start-page: 15091 year: 2006 ident: key 20170522124519_DDS155C23 article-title: DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0607260103 contributor: fullname: Clements – volume: 256 start-page: 89 year: 1999 ident: key 20170522124519_DDS155C20 article-title: Increase in three alpha,beta-dicarbonyl compound levels in human uremic plasma: specific in vivo determination of intermediates in advanced Maillard reaction publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1999.0221 contributor: fullname: Odani – volume: 68 start-page: 1433 year: 2004 ident: key 20170522124519_DDS155C29 article-title: The cytotoxic mechanism of glyoxal involves oxidative stress publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2004.06.013 contributor: fullname: Shangari – volume: 81 start-page: 926 year: 2011 ident: key 20170522124519_DDS155C18 article-title: Hsp31 of Escherichia coli K-12 is glyoxalase III publication-title: Mol. Microbiol. doi: 10.1111/j.1365-2958.2011.07736.x contributor: fullname: Subedi – volume: 47 start-page: 1354 year: 2009 ident: key 20170522124519_DDS155C35 article-title: DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2009.08.003 contributor: fullname: Kahle – volume: 468 start-page: 696 year: 2010 ident: key 20170522124519_DDS155C4 article-title: Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1 publication-title: Nature doi: 10.1038/nature09536 contributor: fullname: Guzman – volume: 24 start-page: 144 year: 2006 ident: key 20170522124519_DDS155C30 article-title: PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2006.06.004 contributor: fullname: Inden – volume: 269 start-page: 1 year: 1990 ident: key 20170522124519_DDS155C15 article-title: The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life publication-title: Biochem. J. doi: 10.1042/bj2690001 contributor: fullname: Thornalley – volume: 99 start-page: 3264 year: 2002 ident: key 20170522124519_DDS155C28 article-title: Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.042497999 contributor: fullname: Nass – volume: 20 start-page: 40 year: 2011 ident: key 20170522124519_DDS155C40 article-title: DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddq430 contributor: fullname: Thomas – volume: 305 start-page: 999 year: 1995 ident: key 20170522124519_DDS155C17 article-title: Glyoxalase III from Escherichia coli: a single novel enzyme for the conversion of methylglyoxal into D-lactate without reduced glutathione publication-title: Biochem. J. doi: 10.1042/bj3050999 contributor: fullname: Misra – volume: 107 start-page: 9747 year: 2010 ident: key 20170522124519_DDS155C41 article-title: DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0911175107 contributor: fullname: Hao – volume: 267 start-page: 4364 year: 1992 ident: key 20170522124519_DDS155C16 article-title: Reduction of trioses by NADPH-dependent aldo-keto reductases. Aldose reductase, methylglyoxal, and diabetic complications publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)42844-X contributor: fullname: Vander Jagt – volume: 15 start-page: 1572 year: 2005 ident: key 20170522124519_DDS155C5 article-title: Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease publication-title: Curr. Biol. doi: 10.1016/j.cub.2005.07.064 contributor: fullname: Meulener – volume: 353 start-page: 678 year: 2005 ident: key 20170522124519_DDS155C32 article-title: The atomic resolution crystal structure of the YajL (ThiJ) protein from Escherichia coli: a close prokaryotic homologue of the Parkinsonism-associated protein DJ-1 publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2005.08.033 contributor: fullname: Wilson – volume: 2 start-page: e327 year: 2004 ident: key 20170522124519_DDS155C7 article-title: Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0020327 contributor: fullname: Martinat – volume: 19 start-page: 3734 year: 2010 ident: key 20170522124519_DDS155C39 article-title: Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddq288 contributor: fullname: Irrcher – volume: 1 start-page: 247 year: 2003 ident: key 20170522124519_DDS155C24 article-title: DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex publication-title: Mol. Cancer Res. contributor: fullname: Niki – volume: 36 start-page: 1045 year: 2008 ident: key 20170522124519_DDS155C38 article-title: Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress publication-title: Biochem. Soc. Trans. doi: 10.1042/BST0361045 contributor: fullname: Rabbani – volume: 283 start-page: 34069 year: 2008 ident: key 20170522124519_DDS155C19 article-title: Crystal structure of filamentous aggregates of human DJ-1 formed in an inorganic phosphate-dependent manner publication-title: J. Biol. Chem. doi: 10.1074/jbc.M804243200 contributor: fullname: Cha – volume: 15 start-page: 211 year: 2005 ident: key 20170522124519_DDS155C13 article-title: Age- and stage-dependent accumulation of advanced glycation end products in intracellular deposits in normal and Alzheimer's disease brains publication-title: Cereb. Cortex doi: 10.1093/cercor/bhh123 contributor: fullname: Luth – volume: 28 start-page: 1044 year: 2007 ident: key 20170522124519_DDS155C37 article-title: Methylglyoxal impairs glucose metabolism and leads to energy depletion in neuronal cells—protection by carbonyl scavengers publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2006.05.007 contributor: fullname: de Arriba – volume: 239 start-page: 1282 year: 2010 ident: key 20170522124519_DDS155C9 article-title: C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease publication-title: Dev. Dyn. doi: 10.1002/dvdy.22231 contributor: fullname: Harrington – volume: 7 start-page: 260 year: 2008 ident: key 20170522124519_DDS155C27 article-title: Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans publication-title: Aging Cell doi: 10.1111/j.1474-9726.2008.00371.x contributor: fullname: Morcos – volume: 20 start-page: 253 year: 2000 ident: key 20170522124519_DDS155C11 article-title: Crosslinking of alpha-synuclein by advanced glycation endproducts—an early pathophysiological step in Lewy body formation? publication-title: J. Chem. Neuroanat. doi: 10.1016/S0891-0618(00)00096-X contributor: fullname: Munch – volume: 231 start-page: 509 year: 1997 ident: key 20170522124519_DDS155C2 article-title: DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1997.6132 contributor: fullname: Nagakubo – volume: 5 start-page: 213 year: 2004 ident: key 20170522124519_DDS155C6 article-title: DJ-1 has a role in antioxidative stress to prevent cell death publication-title: EMBO Rep. doi: 10.1038/sj.embor.7400074 contributor: fullname: Taira – volume: 77 start-page: 71 year: 1974 ident: key 20170522124519_DDS155C42 article-title: The genetics of Caenorhabditis elegans publication-title: Genetics doi: 10.1093/genetics/77.1.71 contributor: fullname: Brenner – volume: 280 start-page: 42655 year: 2005 ident: key 20170522124519_DDS155C8 article-title: Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans publication-title: J. Biol. Chem. doi: 10.1074/jbc.M505910200 contributor: fullname: Ved – volume: 46 start-page: 223 year: 1995 ident: key 20170522124519_DDS155C12 article-title: Advanced protein glycosylation in diabetes and aging publication-title: Annu. Rev. Med. doi: 10.1146/annurev.med.46.1.223 contributor: fullname: Brownlee – volume: 443 start-page: 213 year: 2012 ident: key 20170522124519_DDS155C22 article-title: Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation publication-title: Biochem. J. doi: 10.1042/BJ20111648 contributor: fullname: Xue – volume: 101 start-page: 9103 year: 2004 ident: key 20170522124519_DDS155C3 article-title: The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0402959101 contributor: fullname: Canet-Aviles – volume: 344 start-page: 109 year: 1999 ident: key 20170522124519_DDS155C10 article-title: Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose publication-title: Biochem. J. doi: 10.1042/bj3440109 contributor: fullname: Thornalley – volume: 68 start-page: 721 year: 2011 ident: key 20170522124519_DDS155C21 article-title: Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress publication-title: Cell Mol. Life Sci. doi: 10.1007/s00018-010-0483-7 contributor: fullname: Kurz – volume: 2 start-page: 36 year: 2009 ident: key 20170522124519_DDS155C33 article-title: Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury publication-title: Oxid. Med. Cell Longev. doi: 10.4161/oxim.2.1.7985 contributor: fullname: Yanagida |
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Snippet | Human DJ-1 is a genetic cause of early-onset Parkinson's disease (PD), although its biochemical function is unknown. We report here that human DJ-1 and its... |
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SubjectTerms | Age Aldehyde Oxidoreductases - chemistry Aldehyde Oxidoreductases - genetics Aldehyde Oxidoreductases - metabolism Amino Acid Sequence Animals Apoptosis Biological and medical sciences Caenorhabditis elegans Caenorhabditis elegans - chemistry Caenorhabditis elegans - enzymology Caenorhabditis elegans - genetics Caenorhabditis elegans Proteins - chemistry Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism carbonyls Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cysteine Dopamine Embryo fibroblasts Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Glutamic acid Glutathione Glyoxal - metabolism Humans Intestine Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kinetics Lactic acid Mice Mice, Inbred C57BL Mice, Knockout Molecular and cellular biology Molecular Sequence Data Movement disorders Neurodegeneration Neurodegenerative diseases Neurons Neurons - cytology Neurons - enzymology Neurons - metabolism Oncogene Proteins - chemistry Oncogene Proteins - genetics Oncogene Proteins - metabolism PARK7 protein Parkinson Disease - enzymology Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson's disease Peroxiredoxins Protein Deglycase DJ-1 Pyruvaldehyde Pyruvaldehyde - metabolism Rats Sequence Alignment |
Title | Human DJ-1 and its homologs are novel glyoxalases |
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