Animal model of uterine adenomyosis: is prolactin a potent inducer of adenomyosis in mice?

Uterine adenomyosis is a benign lesion but a serious disease for women, because the symptoms are characterized by abnormal bleeding, pain, cramps, and sterility. Thus elucidation of the mechanisms involved in the development of the disease would contribute to improved management and treatment and pr...

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Bibliographic Details
Published inAmerican journal of obstetrics and gynecology Vol. 165; no. 1; p. 232
Main Authors Mori, T, Singtripop, T, Kawashima, S
Format Journal Article
LanguageEnglish
Published United States 01.07.1991
Subjects
Animals
Disease Models, Animal
Endometriosis - chemically induced
Endometriosis - etiology
Endometriosis - pathology
Mice
Microscopy, Electron
Prolactin
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Summary:Uterine adenomyosis is a benign lesion but a serious disease for women, because the symptoms are characterized by abnormal bleeding, pain, cramps, and sterility. Thus elucidation of the mechanisms involved in the development of the disease would contribute to improved management and treatment and prophylaxis of this lesion. A mouse model, in which ectopic pituitary isografting is associated with an increase in the plasma level of prolactin, is useful for a rapid and frequent induction of uterine adenomyosis and can be used to study the origin of this lesion.
ISSN:0002-9378
1097-6868
DOI:10.1016/0002-9378(91)90258-S