Arterial Stiffness Assessment Using the Arteriograph in Patients with Moderate–Severe OSA and Metabolic Syndrome—A Pilot Study
Background: Both obstructive sleep apnea (OSA) and metabolic syndrome (MS) promote arterial stiffening. As a basis for this study, we presumed that arterial stiffness could be assessed using the Arteriograph (TensioMed, Budapest, Hungary) to detect early modifications induced by continuous positive...
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Published in | Journal of clinical medicine Vol. 10; no. 18; p. 4238 |
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Abstract | Background: Both obstructive sleep apnea (OSA) and metabolic syndrome (MS) promote arterial stiffening. As a basis for this study, we presumed that arterial stiffness could be assessed using the Arteriograph (TensioMed, Budapest, Hungary) to detect early modifications induced by continuous positive airway therapy (CPAP) in reversing this detrimental vascular remodeling. Arterial stiffness is increasingly acknowledged as a major cardiovascular risk factor and a marker of subclinical hypertension-mediated organ damage. The aim of this pilot study was to evaluate the arterial stiffness changes in patients with moderate–severe OSA and MS after short-term CPAP use. Methods: We performed a prospective study that included patients with moderate–severe OSA and MS who had not undergone previous CPAP therapy. All subjects underwent clinical examination and arterial stiffness assessment using the oscillometric technique with Arteriograph (TensioMed, Budapest, Hungary) detection before and after 8-week CPAP therapy. Results: 39 patients with moderate–severe OSA were included. Eight weeks of CPAP therapy significantly improved central systolic blood pressure (Δ = −11.4 mmHg, p = 0.009), aortic pulse wave velocity (aoPWV: Δ = −0.66 m/s, p = 0.03), and aortic augmentation index (aoAix: Δ = −8.25%, p = 0.01) only in patients who used the device for a minimum of 4 h/night (n = 20). Conclusions: Arterial stiffness was improved only among CPAP adherent patients and could be detected using the Arteriograph (TensioMed, Budapest, Hungary), which involves a noninvasive procedure that is easy to implement for the clinical evaluation of arterial stiffness. |
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AbstractList | Background: Both obstructive sleep apnea (OSA) and metabolic syndrome (MS) promote arterial stiffening. As a basis for this study, we presumed that arterial stiffness could be assessed using the Arteriograph (TensioMed, Budapest, Hungary) to detect early modifications induced by continuous positive airway therapy (CPAP) in reversing this detrimental vascular remodeling. Arterial stiffness is increasingly acknowledged as a major cardiovascular risk factor and a marker of subclinical hypertension-mediated organ damage. The aim of this pilot study was to evaluate the arterial stiffness changes in patients with moderate–severe OSA and MS after short-term CPAP use. Methods: We performed a prospective study that included patients with moderate–severe OSA and MS who had not undergone previous CPAP therapy. All subjects underwent clinical examination and arterial stiffness assessment using the oscillometric technique with Arteriograph (TensioMed, Budapest, Hungary) detection before and after 8-week CPAP therapy. Results: 39 patients with moderate–severe OSA were included. Eight weeks of CPAP therapy significantly improved central systolic blood pressure (Δ = −11.4 mmHg, p = 0.009), aortic pulse wave velocity (aoPWV: Δ = −0.66 m/s, p = 0.03), and aortic augmentation index (aoAix: Δ = −8.25%, p = 0.01) only in patients who used the device for a minimum of 4 h/night (n = 20). Conclusions: Arterial stiffness was improved only among CPAP adherent patients and could be detected using the Arteriograph (TensioMed, Budapest, Hungary), which involves a noninvasive procedure that is easy to implement for the clinical evaluation of arterial stiffness. Background: Both obstructive sleep apnea (OSA) and metabolic syndrome (MS) promote arterial stiffening. As a basis for this study, we presumed that arterial stiffness could be assessed using the Arteriograph (TensioMed, Budapest, Hungary) to detect early modifications induced by continuous positive airway therapy (CPAP) in reversing this detrimental vascular remodeling. Arterial stiffness is increasingly acknowledged as a major cardiovascular risk factor and a marker of subclinical hypertension-mediated organ damage. The aim of this pilot study was to evaluate the arterial stiffness changes in patients with moderate–severe OSA and MS after short-term CPAP use. Methods: We performed a prospective study that included patients with moderate–severe OSA and MS who had not undergone previous CPAP therapy. All subjects underwent clinical examination and arterial stiffness assessment using the oscillometric technique with Arteriograph (TensioMed, Budapest, Hungary) detection before and after 8-week CPAP therapy. Results: 39 patients with moderate–severe OSA were included. Eight weeks of CPAP therapy significantly improved central systolic blood pressure (Δ = −11.4 mmHg, p = 0.009), aortic pulse wave velocity (aoPWV: Δ = −0.66 m/s, p = 0.03), and aortic augmentation index (aoAix: Δ = −8.25%, p = 0.01) only in patients who used the device for a minimum of 4 h/night ( n = 20). Conclusions: Arterial stiffness was improved only among CPAP adherent patients and could be detected using the Arteriograph (TensioMed, Budapest, Hungary), which involves a noninvasive procedure that is easy to implement for the clinical evaluation of arterial stiffness. BACKGROUNDBoth obstructive sleep apnea (OSA) and metabolic syndrome (MS) promote arterial stiffening. As a basis for this study, we presumed that arterial stiffness could be assessed using the Arteriograph (TensioMed, Budapest, Hungary) to detect early modifications induced by continuous positive airway therapy (CPAP) in reversing this detrimental vascular remodeling. Arterial stiffness is increasingly acknowledged as a major cardiovascular risk factor and a marker of subclinical hypertension-mediated organ damage. The aim of this pilot study was to evaluate the arterial stiffness changes in patients with moderate-severe OSA and MS after short-term CPAP use. METHODSWe performed a prospective study that included patients with moderate-severe OSA and MS who had not undergone previous CPAP therapy. All subjects underwent clinical examination and arterial stiffness assessment using the oscillometric technique with Arteriograph (TensioMed, Budapest, Hungary) detection before and after 8-week CPAP therapy. RESULTS39 patients with moderate-severe OSA were included. Eight weeks of CPAP therapy significantly improved central systolic blood pressure (Δ = -11.4 mmHg, p = 0.009), aortic pulse wave velocity (aoPWV: Δ = -0.66 m/s, p = 0.03), and aortic augmentation index (aoAix: Δ = -8.25%, p = 0.01) only in patients who used the device for a minimum of 4 h/night (n = 20). CONCLUSIONSArterial stiffness was improved only among CPAP adherent patients and could be detected using the Arteriograph (TensioMed, Budapest, Hungary), which involves a noninvasive procedure that is easy to implement for the clinical evaluation of arterial stiffness. |
Author | Anghel, Razvan Mitu, Florin Stătescu, Cristian Ghiciuc, Cristina Mihaela Cozma, Sebastian Romica Roca, Mihai Dima-Cozma, Lucia Corina Boisteanu, Daniela Mitu, Ovidiu Anghel, Larisa Sascău, Radu Andy Zota, Ioana Mădălina |
AuthorAffiliation | 3 Department of Medical Specialties (III), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, Romania; daniela.boisteanu@umfiasi.ro 1 Department of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, Romania; ioana-madalina.chiorescu@umfiasi.ro (I.M.Z.); cristian.statescu@umfiasi.ro (C.S.); radu.sascau@umfiasi.ro (R.A.S.); mihai.c.roca@umfiasi.ro (M.R.); larisa.anghel@umfiasi.ro (L.A.); ovidiu.mitu@umfiasi.ro (O.M.); razvan.anghel@umfiasi.ro (R.A.); cozma.dima@umfiasi.ro (L.C.D.-C.); florin.mitu@umfiasi.ro (F.M.) 4 Department of Surgery (II), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, Romania; sebastian.cozma@umfiasi.ro 2 Department of Morpho-Functional Sciences (II), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, Romania |
AuthorAffiliation_xml | – name: 4 Department of Surgery (II), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, Romania; sebastian.cozma@umfiasi.ro – name: 2 Department of Morpho-Functional Sciences (II), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, Romania – name: 1 Department of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, Romania; ioana-madalina.chiorescu@umfiasi.ro (I.M.Z.); cristian.statescu@umfiasi.ro (C.S.); radu.sascau@umfiasi.ro (R.A.S.); mihai.c.roca@umfiasi.ro (M.R.); larisa.anghel@umfiasi.ro (L.A.); ovidiu.mitu@umfiasi.ro (O.M.); razvan.anghel@umfiasi.ro (R.A.); cozma.dima@umfiasi.ro (L.C.D.-C.); florin.mitu@umfiasi.ro (F.M.) – name: 3 Department of Medical Specialties (III), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, Romania; daniela.boisteanu@umfiasi.ro |
Author_xml | – sequence: 1 givenname: Ioana Mădălina orcidid: 0000-0003-4053-4130 surname: Zota fullname: Zota, Ioana Mădălina – sequence: 2 givenname: Cristian surname: Stătescu fullname: Stătescu, Cristian – sequence: 3 givenname: Radu Andy surname: Sascău fullname: Sascău, Radu Andy – sequence: 4 givenname: Mihai surname: Roca fullname: Roca, Mihai – sequence: 5 givenname: Larisa surname: Anghel fullname: Anghel, Larisa – sequence: 6 givenname: Ovidiu orcidid: 0000-0002-9438-8565 surname: Mitu fullname: Mitu, Ovidiu – sequence: 7 givenname: Cristina Mihaela orcidid: 0000-0003-1791-0425 surname: Ghiciuc fullname: Ghiciuc, Cristina Mihaela – sequence: 8 givenname: Daniela surname: Boisteanu fullname: Boisteanu, Daniela – sequence: 9 givenname: Razvan surname: Anghel fullname: Anghel, Razvan – sequence: 10 givenname: Sebastian Romica orcidid: 0000-0002-3768-6232 surname: Cozma fullname: Cozma, Sebastian Romica – sequence: 11 givenname: Lucia Corina surname: Dima-Cozma fullname: Dima-Cozma, Lucia Corina – sequence: 12 givenname: Florin surname: Mitu fullname: Mitu, Florin |
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Snippet | Background: Both obstructive sleep apnea (OSA) and metabolic syndrome (MS) promote arterial stiffening. As a basis for this study, we presumed that arterial... BACKGROUNDBoth obstructive sleep apnea (OSA) and metabolic syndrome (MS) promote arterial stiffening. As a basis for this study, we presumed that arterial... |
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SubjectTerms | adherence arterial stiffness Arteriograph Blood pressure Clinical medicine continuous positive airway pressure (CPAP) Hypertension Metabolic syndrome metabolic syndrome (MS) Mortality obstructive sleep apnea (OSA) Questionnaires Sleep apnea Software Values |
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Title | Arterial Stiffness Assessment Using the Arteriograph in Patients with Moderate–Severe OSA and Metabolic Syndrome—A Pilot Study |
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