Age-dependent effects of the β3 adrenoceptor agonist CL316,243 on human and rat detrusor muscle strips

• Published in: Pflügers Archiv Vol. 476; no. 2; pp. 243 - 256
• Main Authors: Petereit, Charlotte, Porath, Katrin, Rackow, Simone, Kernig, Karoline, Hakenberg, Oliver W., Köhling, Rüdiger, Kirschstein, Timo
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2024; Springer Nature B.V
• Subjects: Adrenergic receptors; Aging; Agonists; Anticholinergics; Biomedical and Life Sciences; Biomedicine; Carbachol; Cell Biology; Constipation; Human Physiology; Immunohistochemistry; Middle age; Molecular Medicine; Muscle contraction; Muscle Physiology; Neurosciences; Potassium chloride; Receptors; Smooth muscle; DAPI; Isometric force; Beta3; Antibody; Patients; Potassium

Motility of detrusor smooth muscle includes adrenergic relaxation and cholinergic contraction. Since the latter may be deregulated in overactive bladder (OAB) pathophysiology, anticholinergics are the standard therapy but occasionally less tolerated due to side effects such as dry mouth and constipa...