Ginseng root extract attenuates inflammation by inhibiting the MAPK/NF-κB signaling pathway and activating autophagy and p62-Nrf2-Keap1 signaling in vitro and in vivo - Yang, Song; Li, Fangyu; Lu, Shuyan; Ren, Limei; Bian, Shuai; Liu, Meichen; Zhao, Daqing; Wang, Siming; Wang, Jiawen (Journal of ethnopharmacology, 2022)
Keywords: Animals; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; autophagosomes; Autophagy; Autophagy - drug effects; colitis; Dextran Sulfate; Disease Models, Animal; enzyme-linked immunosorbent assay; fluorescence; fluorescence microscopy; Gene Knockdown Techniques; Ginseng root extract; Inflammation; Inflammation - drug therapy; interleukin-10; interleukin-6; Kelch-Like ECH-Associated Protein 1 - metabolism; Male; males; MAP Kinase Signaling System - drug effects; MAPK/NF-κB; membrane potential; Mice; Mice, Inbred C57BL; mitochondria; mitochondrial membrane; NF-E2-Related Factor 2 - metabolism; NF-kappa B - metabolism; nitric oxide; oxidation; Oxidative damage; oxidative stress; Oxidative Stress - drug effects; p62-Nrf2-Keap1; Panax - chemistry; Panax ginseng; phosphorylation; Plant Extracts - pharmacology; protein synthesis; quantitative polymerase chain reaction; RAW 264.7 Cells; root extracts; Signal Transduction - drug effects; traditional medicine; transmission electron microscopy; p62-Nrf2-Keap1; Inflammation; Oxidative damage; MAPK/NF-κB; Autophagy; Ginseng root extract