αII-Spectrin Breakdown Products (SBDPs): Diagnosis and Outcome in Severe Traumatic Brain Injury Patients

• Published in: Journal of neurotrauma Vol. 27; no. 7; pp. 1203 - 1213
• Main Authors: Mondello, Stefania, Robicsek, Steven A., Gabrielli, Andrea, Brophy, Gretchen M., Papa, Linda, Tepas, Joseph, Robertson, Claudia, Buki, Andras, Scharf, Dancia, Jixiang, Mo, Akinyi, Linnet, Muller, Uwe, Wang, Kevin K.W., Hayes, Ronald L.
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.07.2010
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers - cerebrospinal fluid; Brain; Brain Injuries - cerebrospinal fluid; Brain Injuries - diagnosis; Brain Injuries - mortality; Cerebrospinal fluid; Female; Humans; Injuries; Male; Middle Aged; Original; Peptide Fragments - cerebrospinal fluid; Physiological aspects; Predictive Value of Tests; Prognosis; Protein Isoforms - cerebrospinal fluid; Severity of Illness Index; Spectrin - cerebrospinal fluid; Survival Rate; Young Adult; United States

In this study we assessed the clinical utility of quantitative assessments of alphaII-spectrin breakdown products (SBDP145 produced by calpain, and SBDP120 produced by caspase-3) in cerebrospinal fluid (CSF) as markers of brain damage and outcome after severe traumatic brain injury (TBI). We analyze...