Unravelling the effects of the environment and host genotype on the gut microbiome

• Published in: Nature reviews. Microbiology Vol. 9; no. 4; pp. 279 - 290
• Main Authors: Spor, Aymé, Koren, Omry, Ley, Ruth
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2011; Nature Publishing Group
• Subjects: 41; 631/208/727; 692/698/2741/2135; Adaptive Immunity - genetics; Animals; Bacteria; Biomedical and Life Sciences; Chronic diseases; Chronic illnesses; Diabetes; Diet; Disease; Environment; Environmental aspects; Environmental effects; Gastrointestinal Tract - immunology; Gastrointestinal Tract - microbiology; Genes; Genetic aspects; Genetics; Genotype; Humans; Immunity, Innate - genetics; Infectious Diseases; Inflammatory bowel disease; Life Sciences; Medical Microbiology; Metagenome - immunology; Metagenome - physiology; Mice; Mice, Inbred Strains; Microbial Consortia - immunology; Microbial Consortia - physiology; Microbiology; Microbiota; Microbiota (Symbiotic organisms); Parasitology; Penis; Physiological aspects; Population structure; Quantitative genetics; review-article; Risk factors; Twin studies; Twins; Vagina; Virology; United States

Key Points The gut microbiota can positively and negatively affect host health, and the specific composition of the microbiota may be important for host health and fitness. Environment factors (diet, host environment, maternal effect, stochasticity, and so on) interact to shape the gut microbiota, b...