Accelerated CD8 + T-cell memory and prime-boost response after dendritic-cell vaccination
Efficient boosting of memory T-cell numbers to protective levels generally requires a relatively long interval between immunizations. Decreasing this interval could be crucial in biodefense and cancer immunotherapy, in which rapid protective responses are essential. Here, we show that vaccination wi...
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Published in | Nature medicine Vol. 11; no. 7; pp. 748 - 756 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Nature Publishing Group
01.07.2005
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Subjects | |
Online Access | Get full text |
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Abstract | Efficient boosting of memory T-cell numbers to protective levels generally requires a relatively long interval between immunizations. Decreasing this interval could be crucial in biodefense and cancer immunotherapy, in which rapid protective responses are essential. Here, we show that vaccination with peptide-coated dendritic cells (DCs) generated CD8+ T cells with the phenotype and function of memory cells within 4-6 d. These early memory CD8+ T cells underwent vigorous secondary expansion in response to a variety of booster immunizations, leading to elevated numbers of effector and memory T cells and enhanced protective immunity. Coinjection of CpG oligodeoxynucleotides, potent inducers of inflammation that did not alter the duration of DC antigen display, prevented the rapid generation of memory T cells in wild-type mice but not in mice lacking the interferon (IFN)-gamma receptor. These data show that DC vaccination stimulates a pathway of accelerated generation of memory T cells, and suggest that events of inflammation, including the action of IFN-gamma on the responding T cells, control the rate of development of memory CD8+ T cells. |
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AbstractList | Efficient boosting of memory T-cell numbers to protective levels generally requires a relatively long interval between immunizations. Decreasing this interval could be crucial in biodefense and cancer immunotherapy, in which rapid protective responses are essential. Here, we show that vaccination with peptide-coated dendritic cells (DCs) generated CD8+ T cells with the phenotype and function of memory cells within 4–6 d. These early memory CD8+ T cells underwent vigorous secondary expansion in response to a variety of booster immunizations, leading to elevated numbers of effector and memory T cells and enhanced protective immunity. Coinjection of CpG oligodeoxynucleotides, potent inducers of inflammation that did not alter the duration of DC antigen display, prevented the rapid generation of memory T cells in wild-type mice but not in mice lacking the interferon (IFN)-γ receptor. These data show that DC vaccination stimulates a pathway of accelerated generation of memory T cells, and suggest that events of inflammation, including the action of IFN-γ on the responding T cells, control the rate of development of memory CD8+ T cells. Efficient boosting of memory T-cell numbers to protective levels generally requires a relatively long interval between immunizations. Decreasing this interval could be crucial in biodefense and cancer immunotherapy, in which rapid protective responses are essential. Here, we show that vaccination with peptide-coated dendritic cells (DCs) generated CD8+ T cells with the phenotype and function of memory cells within 4-6 d. These early memory CD8+ T cells underwent vigorous secondary expansion in response to a variety of booster immunizations, leading to elevated numbers of effector and memory T cells and enhanced protective immunity. Coinjection of CpG oligodeoxynucleotides, potent inducers of inflammation that did not alter the duration of DC antigen display, prevented the rapid generation of memory T cells in wild-type mice but not in mice lacking the interferon (IFN)-gamma receptor. These data show that DC vaccination stimulates a pathway of accelerated generation of memory T cells, and suggest that events of inflammation, including the action of IFN-gamma on the responding T cells, control the rate of development of memory CD8+ T cells. |
Audience | Academic |
Author | Haring, Jodie S Badovinac, Vladimir P Jabbari, Ali Messingham, Kelly A N Harty, John T |
Author_xml | – sequence: 1 givenname: John T surname: Harty fullname: Harty, John T organization: Department of Microbiology, 3-512 Bowen Science Building, 51 Newton Road, University of Iowa Interdisciplinary Graduate Program in Immunology, University of Iowa, 1190 Medical Laboratories – sequence: 2 givenname: Vladimir P surname: Badovinac fullname: Badovinac, Vladimir P organization: Department of Microbiology, 3-512 Bowen Science Building, 51 Newton Road, University of Iowa – sequence: 3 givenname: Kelly A N surname: Messingham fullname: Messingham, Kelly A N organization: Department of Microbiology, 3-512 Bowen Science Building, 51 Newton Road, University of Iowa – sequence: 4 givenname: Ali surname: Jabbari fullname: Jabbari, Ali organization: Interdisciplinary Graduate Program in Immunology, University of Iowa, 1190 Medical Laboratories – sequence: 5 givenname: Jodie S surname: Haring fullname: Haring, Jodie S organization: Department of Microbiology, 3-512 Bowen Science Building, 51 Newton Road, University of Iowa |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15951824$$D View this record in MEDLINE/PubMed |
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ContentType | Journal Article |
Copyright | COPYRIGHT 2005 Nature Publishing Group Copyright Nature Publishing Group Jul 2005 Nature Publishing Group 2005. |
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Snippet | Efficient boosting of memory T-cell numbers to protective levels generally requires a relatively long interval between immunizations. Decreasing this interval... |
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SubjectTerms | Animals Antigens Cancer immunotherapy CD8 antigen CD8-Positive T-Lymphocytes - immunology CpG Islands Dendritic cells Dendritic Cells - immunology Effector cells Genotype & phenotype Immunization, Secondary Immunologic Memory Immunological memory Immunotherapy Infections Inflammation Inflammation - immunology Inflammation - metabolism Interferon Interferon gamma Receptor Interferon-gamma - metabolism Listeria monocytogenes - immunology Listeria monocytogenes - pathogenicity Lymphocytes Lymphocytes T Medical laboratories Memory cells Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Mutant Strains Oligonucleotides Peptides Phenotypes Receptors, Interferon - genetics Receptors, Interferon - metabolism Spleen Vaccination Vaccination - methods Vaccines Virulence γ-Interferon |
Title | Accelerated CD8 + T-cell memory and prime-boost response after dendritic-cell vaccination |
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