NOX4–TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming

• Published in: The Journal of biological chemistry Vol. 299; no. 5; p. 104695
• Main Authors: Pandey, Jyotsana, Larson-Casey, Jennifer L., Patil, Mallikarjun H., Joshi, Rutwij, Jiang, Chun-sun, Zhou, Yong, He, Chao, Carter, A. Brent
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2023; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Fibrosis; Humans; macrophage; Macrophages, Alveolar - metabolism; Mice; mitochondria; Mitochondria - metabolism; NADPH Oxidase 4 - genetics; NADPH Oxidase 4 - metabolism; NOX4; OPXPHOS; Reactive Oxygen Species - metabolism; TIM23; NADPH; IM; MMVF; mitochondria; ROS; TMB; macrophage; NOX4; TIM23; M; OPXPHOS; IMS

Pulmonary fibrosis is a progressive lung disease characterized by macrophage activation. Asbestos-induced expression of nicotinamide adenine dinucleotide phosphate hydrogen oxidase 4 (NOX4) in lung macrophages mediates fibrotic progression by the generation of mitochondrial reactive oxygen species (...