Effects of naturally occurring flavonoids on mitogen-induced lymphocyte proliferation and mixed lymphocyte culture

• Published in: Life sciences (1973) Vol. 54; no. 5; pp. 313 - 320
• Main Authors: Namgoong, S.Y., Son, K.H., Chang, H.W., Kang, S.S., Kim, H.P.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 1994; Elsevier
• Subjects: Animals; Biological and medical sciences; Concanavalin A - pharmacology; Flavonoids - pharmacology; General pharmacology; Glycosides - pharmacology; Lipopolysaccharides - pharmacology; Lymphocyte Activation - drug effects; Lymphocyte Culture Test, Mixed; Male; Medical sciences; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mitogens - pharmacology; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Spleen - cytology; Spleen - drug effects; Stimulation, Chemical; Cell proliferation; Immunomodulation; Pharmacognosy; Rodentia; Flavonoid; In vitro; Medicinal plant; Vertebrata; Mammalia; Structure activity relation; Mouse; Animal; Plant origin; Immunosuppressive agent; Lymphocyte

In this investigation, 34 structurally different flavonoids including derivatives of chalcone, flavanone, flavan-3-ol, flavone, flavonol, and their glycosides were evaluated for in vitro suppression of mitogen-induced lymphocyte proliferation and mixed lymphocyte culture from mouse spleen. Flavonoid...