Identification of short-term pharmacodynamic effects of interferon-beta-1a in multiple sclerosis subjects with broad- based phenotypic profiling

• Published in: Journal of neuroimmunology Vol. 188; no. 1; pp. 103 - 116
• Main Authors: Kantor, Aaron B, Deng, Jun, Waubant, Emmanuelle, Lin, Hua, Becker, Christopher H, Lacy, Joseph R, Perrone, Andrea M, Bennett, Donald, Goelz, Susan E
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2007
• Subjects: Adjuvants, Immunologic - pharmacology; Adjuvants, Immunologic - therapeutic use; Allergy and Immunology; Antigens, CD - metabolism; B-Lymphocytes - drug effects; Biomarkers; Cluster Analysis; Cohort Studies; Cytokines - metabolism; GTP-Binding Proteins - metabolism; Histocompatibility Antigens Class II - metabolism; Humans; Immunoassay - methods; Interferon beta-1a; Interferon-beta; Interferon-beta - pharmacology; Interferon-beta - therapeutic use; Mass Spectrometry - methods; Monocytes; Monocytes - drug effects; Monocytes - metabolism; Multiple sclerosis; Multiple Sclerosis - drug therapy; Multiple Sclerosis - pathology; Myxovirus Resistance Proteins; Neurology; Neutrophils - drug effects; Pharmacodynamics; Proteomics - methods; Systems biology; Time Factors; Biomarkers; Multiple sclerosis; Pharmacodynamics; Monocytes; Interferon-beta; Systems biology

Abstract We applied broad-based phenotypic profiling to identify pharmacodynamic markers for interferon-beta in multiple sclerosis subjects. A strong pharmacodynamic effect was observed 1.5 (short-term) vs. 6 days post weekly injection. Hundreds of differences were observed at a p -value < 0.001....