A facile method of using sulfobetaine-containing copolymers for biofouling resistance

• Published in: Journal of applied polymer science Vol. 131; no. 18; pp. 9432 - n/a
• Main Authors: Liu, Qingsheng, Li, Wenchen, Wang, Hua, Liu, Lingyun
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Blackwell Publishing Ltd 15.09.2014; Wiley; Wiley Subscription Services, Inc
• Subjects: Adsorption; Antifouling; Applied sciences; Aqueous environments; Biofouling; Biological and medical sciences; biomaterials; biomedical applications; Biomedical materials; Blood plasma; Chemical synthesis; coatings; Composition; Contact angle; Copolymers; Endothelial cells; Exact sciences and technology; Fibrinogen; Human; Materials science; Medical sciences; NMR; Nuclear magnetic resonance; Organic polymers; Physicochemistry of polymers; Polybutyl methacrylates; Polymers; Polymers with particular properties; Preparation, kinetics, thermodynamics, mechanism and catalysts; Protein adsorption; Proteins; Serums; Surface chemistry; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology. Biomaterials. Equipments; copolymers; Endothelial cell; adsorption; Coating material; Polyampholyte; Property composition relationship; Molecular structure; Liquid solid adsorption; Quaternary ammonium copolymer; Experimental study; Sulfonate copolymer; Random copolymer; Wettability; coatings; Biofouling; Preparation; biomedical applications; Cell adhesion; Surface properties; Biomaterial; Methacrylate copolymer; biomaterials; Radical copolymerization; Butyl methacrylate copolymer
• DOI: 10.1002/app.40789
• ISSN: 0021-8995

ABSTRACT Antifouling materials are desirable for many biomedical applications. In this work, the poly(sulfobetaine methacrylate‐ co ‐butyl methacrylate) (PSB) copolymers were investigated for their antifouling properties. The copolymers were synthesized via a simple free‐radical polymerization with feed ratio of the zwitterionic sulfobetaine methacrylate (SBMA) varying from 0 to 20 mol %. The polymer composition was verified by nuclear magnetic resonance. The enzyme‐linked immunosorbent assay and surface plasmon resonance were used to evaluate protein adsorption on a series of PSB copolymers from the single protein solution of fibrinogen, undiluted human blood serum, and undiluted human blood plasma. Results show that the protein adsorption amount decreased with the increasing content of SBMA in the copolymers. The adsorption levels achieved by PSB containing 20 mol % SBMA (PSB20) were only 4, 17, and 15 ng/cm 2 from fibrinogen, serum, and plasma, respectively, which represented 99%, 90%, and 90% reduction compared with the adsorption amounts on poly(butyl methacrylate) with no SBMA. The PSB20 film also completely inhibited endothelial cell attachment. Fouling resistance of PSB polymers can be well correlated with their receding water contact angles, which represent the polymer surface compositions in aqueous environment. The excellent antifouling abilities of PSB copolymers, combined with the facial synthesis method, commercial availability of all monomers, and low cost, render them highly promising for wide practical applications. The polymers can be applied versatilely as both solvent‐cast films and surface coatings. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40789.