Simultaneous separation and detection of nine kynurenine pathway metabolites by reversed-phase liquid chromatography-mass spectrometry: Quantitation of inflammation in human cerebrospinal fluid and plasma

• Published in: Analytica chimica acta Vol. 1278; p. 341659
• Main Authors: Patel, Vijay D., Shamsi, Shahab A., Miller, Andrew, Liu, Aimin, Powell, Mark
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 16.10.2023
• Subjects: Chromatography, Liquid; Chromatography, Reverse-Phase; Human cerebrospinal fluid and plasma; Humans; Inflammation - diagnosis; Kynurenine; Kynurenine pathway metabolites; Quantitation; Simultaneous separation; Solid-liquid extraction; Tandem Mass Spectrometry; Kynurenine pathway metabolites; Simultaneous separation; Quantitation; Solid-liquid extraction; Human cerebrospinal fluid and plasma
• ISSN: 0003-2670; 1873-4324; 1873-4324
• DOI: 10.1016/j.aca.2023.341659

The kynurenine pathway (KP) generates eight tryptophan (TRP) metabolites collectively called kynurenines, which have gained enormous interest in clinical research. The importance of KP for different disease states calls for developing a low-cost and high-throughput chromatography-mass spectrometry m...