Evaluation on the antiviral activity of genipin against white spot syndrome virus in crayfish

• Published in: Fish & shellfish immunology Vol. 93; pp. 380 - 386
• Main Authors: Huang, Ai-Guo, Tan, Xiao-Ping, Qu, Shen-Ye, Wang, Gao-Xue, Zhu, Bin
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2019
• Subjects: Animals; Antiviral Agents - pharmacology; antiviral properties; Astacoidea - physiology; Astacoidea - virology; Bax inhibitor-1; bioactive compounds; crayfish; Dose-Response Relationship, Drug; fruits; Gardenia jasminoides; gene expression; gene expression regulation; genes; Genipin; immunology; Iridoids - pharmacology; Litopenaeus vannamei; mortality; oxidative stress; pathogens; Penaeidae - physiology; Penaeidae - virology; plant extracts; Procambarus clarkii; Random Allocation; shrimp; signal transduction; STAT; therapeutics; transactivators; transcription (genetics); virus replication; White spot syndrome virus; White spot syndrome virus 1 - drug effects; WSSV; STAT; Bax inhibitor-1; Procambarus clarkii; Litopenaeus vannamei; WSSV; Genipin

White spot syndrome virus (WSSV) is a serious epidemic pathogen of crustaceans and cause severe economic losses to aquaculture. However, no commercial drugs presently available to control WSSV infection. Genipin (GN) is a bioactive compound extracted from the fruit of Gardenia jasminoides and exhibi...