Effects of n-3 PUFA supplementation on plasma soluble adhesion molecules: a meta-analysis of randomized controlled trials
Previous studies indicate that oral supplementation with n-3 PUFA protects against atherosclerotic disease by inhibiting inflammatory processes, which underlie atherosclerosis and are reflected by the plasma concentrations of soluble adhesion molecules. However, consistent results were not obtained...
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| Published in | The American journal of clinical nutrition Vol. 95; no. 4; pp. 972 - 980 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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Bethesda, MD
American Society for Nutrition
01.04.2012
American Society for Clinical Nutrition, Inc |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Previous studies indicate that oral supplementation with n-3 PUFA protects against atherosclerotic disease by inhibiting inflammatory processes, which underlie atherosclerosis and are reflected by the plasma concentrations of soluble adhesion molecules. However, consistent results were not obtained among studies.
The objective was to assess the effects of n-3 PUFA supplementation on plasma concentrations of soluble adhesion molecules.
We conducted a meta-analysis of randomized controlled trials identified from PubMed, Embase, the Cochrane Library, and reference lists of relevant articles and reviews.
Eighteen studies were included. n-3 PUFA supplementation reduced plasma concentrations of soluble intercellular adhesion molecule-1 [sICAM-1; weighted mean difference (WMD): -5.17; 95% CI: -10.07, -0.27; P = 0.04] but had no significant effects on soluble vascular cell adhesion molecule-1 (WMD: -5.90; 95% CI: -17.63, 5.84; P = 0.32), soluble P-selectin (WMD: -1.53; 95% CI: -4.33, 1.28; P = 0.29), or soluble E-selectin (WMD: 0.46; 95% CI: -1.54, 2.46; P = 0.65). Subgroup analysis stratified by the subjects' health status showed that n-3 PUFA supplementation reduced sICAM-1 concentrations in healthy subjects (WMD: -8.87; 95% CI: -15.20, -2.53; P = 0.006; heterogeneity test: I² = 0%, P = 0.76) and in subjects with dyslipidemia (WMD: -15.31; 95% CI: -26.82, -3.81; P = 0.009; heterogeneity test: I² = 26%, P = 0.26).
n-3 PUFA supplementation can reduce plasma concentrations of sICAM-1. The effect is identified in both healthy subjects and subjects with dyslipidemia, which supports the hypothesis that n-3 PUFA can be supplemented as a primary or secondary means for preventing the development as well as the progression of atherosclerosis. |
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| AbstractList | BACKGROUND: Previous studies indicate that oral supplementation with n–3 PUFA protects against atherosclerotic disease by inhibiting inflammatory processes, which underlie atherosclerosis and are reflected by the plasma concentrations of soluble adhesion molecules. However, consistent results were not obtained among studies. OBJECTIVE: The objective was to assess the effects of n–3 PUFA supplementation on plasma concentrations of soluble adhesion molecules. DESIGN: We conducted a meta-analysis of randomized controlled trials identified from PubMed, Embase, the Cochrane Library, and reference lists of relevant articles and reviews. RESULTS: Eighteen studies were included. n–3 PUFA supplementation reduced plasma concentrations of soluble intercellular adhesion molecule-1 [sICAM-1; weighted mean difference (WMD): –5.17; 95% CI: –10.07, –0.27; P = 0.04] but had no significant effects on soluble vascular cell adhesion molecule-1 (WMD: –5.90; 95% CI: –17.63, 5.84; P = 0.32), soluble P-selectin (WMD: –1.53; 95% CI: –4.33, 1.28; P = 0.29), or soluble E-selectin (WMD: 0.46; 95% CI: –1.54, 2.46; P = 0.65). Subgroup analysis stratified by the subjects’ health status showed that n–3 PUFA supplementation reduced sICAM-1 concentrations in healthy subjects (WMD: –8.87; 95% CI: –15.20, –2.53; P = 0.006; heterogeneity test: I2 = 0%, P = 0.76) and in subjects with dyslipidemia (WMD: –15.31; 95% CI: –26.82, –3.81; P = 0.009; heterogeneity test: I2 = 26%, P = 0.26). CONCLUSIONS: n–3 PUFA supplementation can reduce plasma concentrations of sICAM-1. The effect is identified in both healthy subjects and subjects with dyslipidemia, which supports the hypothesis that n–3 PUFA can be supplemented as a primary or secondary means for preventing the development as well as the progression of atherosclerosis. Previous studies indicate that oral supplementation with n-3 PUFA protects against atherosclerotic disease by inhibiting inflammatory processes, which underlie atherosclerosis and are reflected by the plasma concentrations of soluble adhesion molecules. However, consistent results were not obtained among studies. The objective was to assess the effects of n-3 PUFA supplementation on plasma concentrations of soluble adhesion molecules. We conducted a meta-analysis of randomized controlled trials identified from PubMed, Embase, the Cochrane Library, and reference lists of relevant articles and reviews. Eighteen studies were included. n-3 PUFA supplementation reduced plasma concentrations of soluble intercellular adhesion molecule-1 [sICAM-1; weighted mean difference (WMD): -5.17; 95% CI: -10.07, -0.27; P = 0.04] but had no significant effects on soluble vascular cell adhesion molecule-1 (WMD: -5.90; 95% CI: -17.63, 5.84; P = 0.32), soluble P-selectin (WMD: -1.53; 95% CI: -4.33, 1.28; P = 0.29), or soluble E-selectin (WMD: 0.46; 95% CI: -1.54, 2.46; P = 0.65). Subgroup analysis stratified by the subjects' health status showed that n-3 PUFA supplementation reduced sICAM-1 concentrations in healthy subjects (WMD: -8.87; 95% CI: -15.20, -2.53; P = 0.006; heterogeneity test: ... = 0%, P = 0.76) and in subjects with dyslipidemia (WMD: -15.31; 95% CI: -26.82, -3.81; P = 0.009; heterogeneity test: ... = 26%, P = 0.26). n-3 PUFA supplementation can reduce plasma concentrations of sICAM-1. The effect is identified in both healthy subjects and subjects with dyslipidemia, which supports the hypothesis that n-3 PUFA can be supplemented as a primary or secondary means for preventing the development as well as the progression of atherosclerosis. (ProQuest: ... denotes formulae/symbols omitted.) Previous studies indicate that oral supplementation with n-3 PUFA protects against atherosclerotic disease by inhibiting inflammatory processes, which underlie atherosclerosis and are reflected by the plasma concentrations of soluble adhesion molecules. However, consistent results were not obtained among studies. The objective was to assess the effects of n-3 PUFA supplementation on plasma concentrations of soluble adhesion molecules. We conducted a meta-analysis of randomized controlled trials identified from PubMed, Embase, the Cochrane Library, and reference lists of relevant articles and reviews. Eighteen studies were included. n-3 PUFA supplementation reduced plasma concentrations of soluble intercellular adhesion molecule-1 [sICAM-1; weighted mean difference (WMD): -5.17; 95% CI: -10.07, -0.27; P = 0.04] but had no significant effects on soluble vascular cell adhesion molecule-1 (WMD: -5.90; 95% CI: -17.63, 5.84; P = 0.32), soluble P-selectin (WMD: -1.53; 95% CI: -4.33, 1.28; P = 0.29), or soluble E-selectin (WMD: 0.46; 95% CI: -1.54, 2.46; P = 0.65). Subgroup analysis stratified by the subjects' health status showed that n-3 PUFA supplementation reduced sICAM-1 concentrations in healthy subjects (WMD: -8.87; 95% CI: -15.20, -2.53; P = 0.006; heterogeneity test: I² = 0%, P = 0.76) and in subjects with dyslipidemia (WMD: -15.31; 95% CI: -26.82, -3.81; P = 0.009; heterogeneity test: I² = 26%, P = 0.26). n-3 PUFA supplementation can reduce plasma concentrations of sICAM-1. The effect is identified in both healthy subjects and subjects with dyslipidemia, which supports the hypothesis that n-3 PUFA can be supplemented as a primary or secondary means for preventing the development as well as the progression of atherosclerosis. Previous studies indicate that oral supplementation with n-3 PUFA protects against atherosclerotic disease by inhibiting inflammatory processes, which underlie atherosclerosis and are reflected by the plasma concentrations of soluble adhesion molecules. However, consistent results were not obtained among studies.BACKGROUNDPrevious studies indicate that oral supplementation with n-3 PUFA protects against atherosclerotic disease by inhibiting inflammatory processes, which underlie atherosclerosis and are reflected by the plasma concentrations of soluble adhesion molecules. However, consistent results were not obtained among studies.The objective was to assess the effects of n-3 PUFA supplementation on plasma concentrations of soluble adhesion molecules.OBJECTIVEThe objective was to assess the effects of n-3 PUFA supplementation on plasma concentrations of soluble adhesion molecules.We conducted a meta-analysis of randomized controlled trials identified from PubMed, Embase, the Cochrane Library, and reference lists of relevant articles and reviews.DESIGNWe conducted a meta-analysis of randomized controlled trials identified from PubMed, Embase, the Cochrane Library, and reference lists of relevant articles and reviews.Eighteen studies were included. n-3 PUFA supplementation reduced plasma concentrations of soluble intercellular adhesion molecule-1 [sICAM-1; weighted mean difference (WMD): -5.17; 95% CI: -10.07, -0.27; P = 0.04] but had no significant effects on soluble vascular cell adhesion molecule-1 (WMD: -5.90; 95% CI: -17.63, 5.84; P = 0.32), soluble P-selectin (WMD: -1.53; 95% CI: -4.33, 1.28; P = 0.29), or soluble E-selectin (WMD: 0.46; 95% CI: -1.54, 2.46; P = 0.65). Subgroup analysis stratified by the subjects' health status showed that n-3 PUFA supplementation reduced sICAM-1 concentrations in healthy subjects (WMD: -8.87; 95% CI: -15.20, -2.53; P = 0.006; heterogeneity test: I² = 0%, P = 0.76) and in subjects with dyslipidemia (WMD: -15.31; 95% CI: -26.82, -3.81; P = 0.009; heterogeneity test: I² = 26%, P = 0.26).RESULTSEighteen studies were included. n-3 PUFA supplementation reduced plasma concentrations of soluble intercellular adhesion molecule-1 [sICAM-1; weighted mean difference (WMD): -5.17; 95% CI: -10.07, -0.27; P = 0.04] but had no significant effects on soluble vascular cell adhesion molecule-1 (WMD: -5.90; 95% CI: -17.63, 5.84; P = 0.32), soluble P-selectin (WMD: -1.53; 95% CI: -4.33, 1.28; P = 0.29), or soluble E-selectin (WMD: 0.46; 95% CI: -1.54, 2.46; P = 0.65). Subgroup analysis stratified by the subjects' health status showed that n-3 PUFA supplementation reduced sICAM-1 concentrations in healthy subjects (WMD: -8.87; 95% CI: -15.20, -2.53; P = 0.006; heterogeneity test: I² = 0%, P = 0.76) and in subjects with dyslipidemia (WMD: -15.31; 95% CI: -26.82, -3.81; P = 0.009; heterogeneity test: I² = 26%, P = 0.26).n-3 PUFA supplementation can reduce plasma concentrations of sICAM-1. The effect is identified in both healthy subjects and subjects with dyslipidemia, which supports the hypothesis that n-3 PUFA can be supplemented as a primary or secondary means for preventing the development as well as the progression of atherosclerosis.CONCLUSIONSn-3 PUFA supplementation can reduce plasma concentrations of sICAM-1. The effect is identified in both healthy subjects and subjects with dyslipidemia, which supports the hypothesis that n-3 PUFA can be supplemented as a primary or secondary means for preventing the development as well as the progression of atherosclerosis. |
| Author | Hui, Rutai Meng, Lin Zheng, Yang Chen, Dongmei Lu, Na Yang, Yang |
| Author_xml | – sequence: 1 givenname: Yang surname: Yang fullname: Yang, Yang – sequence: 2 givenname: Na surname: Lu fullname: Lu, Na – sequence: 3 givenname: Dongmei surname: Chen fullname: Chen, Dongmei – sequence: 4 givenname: Lin surname: Meng fullname: Meng, Lin – sequence: 5 givenname: Yang surname: Zheng fullname: Zheng, Yang – sequence: 6 givenname: Rutai surname: Hui fullname: Hui, Rutai |
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| Cites_doi | 10.1056/NEJMra1008153 10.1056/NEJM198803033180905 10.1016/j.plefa.2008.02.002 10.1016/S0021-9150(03)00097-2 10.1159/000073852 10.1161/01.ATV.17.11.2576 10.1016/j.thromres.2005.07.018 10.1056/NEJM199606063342308 10.1097/00007890-199612150-00020 10.1016/0167-5699(93)90267-O 10.1172/JCI114562 10.1016/j.numecd.2007.11.007 10.1046/j.1365-2362.1998.00336.x 10.1038/ejcn.2009.63 10.1159/000073601 10.1161/01.ATV.14.11.1829 10.1007/BF02536326 10.1177/147323000903700619 10.1016/j.ijcard.2003.07.014 10.1007/s11745-997-0145-6 10.1016/j.plipres.2008.01.004 10.1160/TH10-01-0008 10.1097/00007890-200108270-00025 10.1161/01.CIR.0000038493.65177.94 10.1161/01.ATV.18.5.723 10.1161/hc0902.104353 10.1016/S0021-9150(02)00307-6 10.1161/01.ATV.13.12.1790 10.1056/NEJM198904063201407 10.1016/S0002-9343(99)00153-9 10.1016/S0049-3848(99)00106-1 10.1093/oxfordjournals.aje.a117615 10.1016/j.atherosclerosis.2004.01.013 10.1016/j.jacc.2011.06.063 10.1080/00365540903168056 10.1111/j.1365-2362.2005.01443.x 10.1007/s11745-001-0831-4 10.1042/cs1000091 10.1161/01.ATV.19.7.1681 10.1016/j.atherosclerosis.2009.03.006 10.1161/01.ATV.15.5.622 10.1016/S0939-4753(04)80002-4 10.1080/003655101316911387 10.1093/ajcn/81.3.583 |
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| References | Price (10.3945/ajcn.111.025924_bib3) 1999; 107 Myrup (10.3945/ajcn.111.025924_bib33) 2001; 61 Brude (10.3945/ajcn.111.025924_bib45) 1997; 17 Erkkilä (10.3945/ajcn.111.025924_bib6) 2008; 47 De Caterina (10.3945/ajcn.111.025924_bib35) 1994; 14 Grundt (10.3945/ajcn.111.025924_bib22) 2003; 33 Seierstad (10.3945/ajcn.111.025924_bib24) 2005; 35 Lussier-Cacan (10.3945/ajcn.111.025924_bib41) 1993; 13 Steinberg (10.3945/ajcn.111.025924_bib43) 1989; 320 Yusof (10.3945/ajcn.111.025924_bib30) 2008; 78 Paulo (10.3945/ajcn.111.025924_bib13) 2008; 18 Seljeflot (10.3945/ajcn.111.025924_bib20) 1998; 28 Blankenberg (10.3945/ajcn.111.025924_bib1) 2003; 170 Woodman (10.3945/ajcn.111.025924_bib14) 2003; 166 Pot (10.3945/ajcn.111.025924_bib17) 2009; 63 Güray (10.3945/ajcn.111.025924_bib5) 2004; 96 Holm (10.3945/ajcn.111.025924_bib40) 2001; 72 Eshcen (10.3945/ajcn.111.025924_bib26) 2010; 56 Nelson (10.3945/ajcn.111.025924_bib32) 1997; 32 Khalfoun (10.3945/ajcn.111.025924_bib37) 1996; 62 Kris-Etherton (10.3945/ajcn.111.025924_bib29) 2002; 106 Thusgaard (10.3945/ajcn.111.025924_bib28) 2009; 41 Di Minno (10.3945/ajcn.111.025924_bib7) 2002; 32 Frankel (10.3945/ajcn.111.025924_bib42) 1994; 29 Johansen (10.3945/ajcn.111.025924_bib25) 1999; 19 Abe (10.3945/ajcn.111.025924_bib21) 1998; 18 Libby (10.3945/ajcn.111.025924_bib2) 2002; 105 Thies (10.3945/ajcn.111.025924_bib12) 2001; 36 Di Minno (10.3945/ajcn.111.025924_bib8) 2010; 104 De Caterina (10.3945/ajcn.111.025924_bib38) 2011; 364 Rizza (10.3945/ajcn.111.025924_bib18) 2009; 206 Conquer (10.3945/ajcn.111.025924_bib31) 1999; 96 Morris (10.3945/ajcn.111.025924_bib9) 1995; 142 Frenette (10.3945/ajcn.111.025924_bib4) 1996; 334 Berliner (10.3945/ajcn.111.025924_bib44) 1990; 85 Weber (10.3945/ajcn.111.025924_bib36) 1995; 15 Leaf (10.3945/ajcn.111.025924_bib10) 1988; 318 10.3945/ajcn.111.025924_bib16 Lee (10.3945/ajcn.111.025924_bib23) 2006; 118 Eschen (10.3945/ajcn.111.025924_bib11) 2004; 14 Rallidis (10.3945/ajcn.111.025924_bib19) 2004; 174 Gearing (10.3945/ajcn.111.025924_bib34) 1993; 14 Mozaffarian (10.3945/ajcn.111.025924_bib39) 2011; 58 Hjerkinn (10.3945/ajcn.111.025924_bib15) 2005; 81 Zhao (10.3945/ajcn.111.025924_bib27) 2009; 37 |
| References_xml | – volume: 364 start-page: 2439 year: 2011 ident: 10.3945/ajcn.111.025924_bib38 article-title: N–3 fatty acids in cardiovascular disease publication-title: N Engl J Med doi: 10.1056/NEJMra1008153 – volume: 318 start-page: 549 year: 1988 ident: 10.3945/ajcn.111.025924_bib10 article-title: Cardiovascular effects of n-3 fatty acids publication-title: N Engl J Med doi: 10.1056/NEJM198803033180905 – volume: 78 start-page: 219 year: 2008 ident: 10.3945/ajcn.111.025924_bib30 article-title: Influence of very long-chain n-3 fatty acids on plasma markers of inflammation in middle-aged men publication-title: Prostaglandins Leukot Essent Fatty Acids doi: 10.1016/j.plefa.2008.02.002 – volume: 170 start-page: 191 year: 2003 ident: 10.3945/ajcn.111.025924_bib1 article-title: Adhesion molecules and atherosclerosis publication-title: Atherosclerosis doi: 10.1016/S0021-9150(03)00097-2 – volume: 33 start-page: 88 year: 2003 ident: 10.3945/ajcn.111.025924_bib22 article-title: Reduction in homocysteine by n-3 polyunsaturated fatty acids after 1 year in a randomised double-blind study following an acute myocardial infarction: no effect on endothelial adhesion properties publication-title: Pathophysiol Haemost Thromb doi: 10.1159/000073852 – volume: 17 start-page: 2576 year: 1997 ident: 10.3945/ajcn.111.025924_bib45 article-title: Peroxidation of LDL from combined-hyperlipidemic male smokers supplied with omega-3 fatty acids and antioxidants publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.17.11.2576 – volume: 118 start-page: 305 year: 2006 ident: 10.3945/ajcn.111.025924_bib23 article-title: Effects of omega-3 polyunsaturated fatty acids on plasma indices of thrombogenesis and inflammation in patients post-myocardial infarction publication-title: Thromb Res doi: 10.1016/j.thromres.2005.07.018 – volume: 334 start-page: 1526 year: 1996 ident: 10.3945/ajcn.111.025924_bib4 article-title: Adhesion molecules. Part 1 publication-title: N Engl J Med doi: 10.1056/NEJM199606063342308 – volume: 62 start-page: 1649 year: 1996 ident: 10.3945/ajcn.111.025924_bib37 article-title: Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte-endothelial cell adhesion publication-title: Transplantation doi: 10.1097/00007890-199612150-00020 – volume: 14 start-page: 506 year: 1993 ident: 10.3945/ajcn.111.025924_bib34 article-title: Circulating adhesion molecules in disease publication-title: Immunol Today doi: 10.1016/0167-5699(93)90267-O – volume: 85 start-page: 1260 year: 1990 ident: 10.3945/ajcn.111.025924_bib44 article-title: Minimally modified low density lipoprotein stimulates monocyte endothelial interactions publication-title: J Clin Invest doi: 10.1172/JCI114562 – volume: 18 start-page: 664 year: 2008 ident: 10.3945/ajcn.111.025924_bib13 article-title: Influence of n-3 polyunsaturated fatty acids on soluble cellular adhesion molecules as biomarkers of cardiovascular risk in young healthy subjects publication-title: Nutr Metab Cardiovasc Dis doi: 10.1016/j.numecd.2007.11.007 – volume: 28 start-page: 629 year: 1998 ident: 10.3945/ajcn.111.025924_bib20 article-title: Effects of omega-3 fatty acids and/or antioxidants on endothelial cell markers publication-title: Eur J Clin Invest doi: 10.1046/j.1365-2362.1998.00336.x – volume: 63 start-page: 1353 year: 2009 ident: 10.3945/ajcn.111.025924_bib17 article-title: No effect of fish oil supplementation on serum inflammatory markers and their interrelationships: a randomized controlled trial in healthy, middle-aged individuals publication-title: Eur J Clin Nutr doi: 10.1038/ejcn.2009.63 – volume: 32 start-page: 361 year: 2002 ident: 10.3945/ajcn.111.025924_bib7 article-title: Polyunsaturated fatty acids, thrombosis and vascular disease publication-title: Pathophysiol Haemost Thromb doi: 10.1159/000073601 – volume: 14 start-page: 1829 year: 1994 ident: 10.3945/ajcn.111.025924_bib35 article-title: The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells publication-title: Arterioscler Thromb doi: 10.1161/01.ATV.14.11.1829 – volume: 29 start-page: 233 year: 1994 ident: 10.3945/ajcn.111.025924_bib42 article-title: Effect of n-3 fatty acid-rich fish oil supplementation on the oxidation of low density lipoproteins publication-title: Lipids doi: 10.1007/BF02536326 – volume: 37 start-page: 1831 year: 2009 ident: 10.3945/ajcn.111.025924_bib27 article-title: Effects of n-3 polyunsaturated fatty acid therapy on plasma inflammatory markers and N-terminal pro-brain natriuretic peptide in elderly patients with chronic heart failure publication-title: J Int Med Res doi: 10.1177/147323000903700619 – volume: 96 start-page: 235 year: 2004 ident: 10.3945/ajcn.111.025924_bib5 article-title: Levels of soluble adhesion molecules in various clinical presentations of coronary atherosclerosis publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2003.07.014 – volume: 32 start-page: 1129 year: 1997 ident: 10.3945/ajcn.111.025924_bib32 article-title: The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans publication-title: Lipids doi: 10.1007/s11745-997-0145-6 – volume: 47 start-page: 172 year: 2008 ident: 10.3945/ajcn.111.025924_bib6 article-title: Dietary fatty acids and cardiovascular disease: an epidemiological approach publication-title: Prog Lipid Res doi: 10.1016/j.plipres.2008.01.004 – volume: 104 start-page: 664 year: 2010 ident: 10.3945/ajcn.111.025924_bib8 article-title: Exploring newer cardioprotective strategies: ω-3 fatty acids in perspective publication-title: Thromb Haemost doi: 10.1160/TH10-01-0008 – volume: 72 start-page: 706 year: 2001 ident: 10.3945/ajcn.111.025924_bib40 article-title: Omega-3 fatty acids enhance tumor necrosis factor-alpha levels in heart transplant recipients publication-title: Transplantation doi: 10.1097/00007890-200108270-00025 – volume: 106 start-page: 2747 year: 2002 ident: 10.3945/ajcn.111.025924_bib29 article-title: AHA Scientific Statement: fish consumption, fish oil, omega-3 fatty acids, and cardiovascular diseases publication-title: Circulation doi: 10.1161/01.CIR.0000038493.65177.94 – volume: 18 start-page: 723 year: 1998 ident: 10.3945/ajcn.111.025924_bib21 article-title: Soluble cell adhesion molecules in hypertriglyceridemia and potential significance on monocyte adhesion publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.18.5.723 – volume: 105 start-page: 1135 year: 2002 ident: 10.3945/ajcn.111.025924_bib2 article-title: Inflammation and atherosclerosis publication-title: Circulation doi: 10.1161/hc0902.104353 – volume: 166 start-page: 85 year: 2003 ident: 10.3945/ajcn.111.025924_bib14 article-title: Effects of purified eicosapentaenoic acid and docosahexaenoic acid on platelet, fibrinolytic and vascular function in hypertensive type 2 diabetic patients publication-title: Atherosclerosis doi: 10.1016/S0021-9150(02)00307-6 – volume: 13 start-page: 1790 year: 1993 ident: 10.3945/ajcn.111.025924_bib41 article-title: Influence of probucol on enhanced LDL oxidation after fish oil treatment of hypertriglyceridemic patients publication-title: Arterioscler Thromb doi: 10.1161/01.ATV.13.12.1790 – volume: 320 start-page: 915 year: 1989 ident: 10.3945/ajcn.111.025924_bib43 article-title: Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity publication-title: N Engl J Med doi: 10.1056/NEJM198904063201407 – volume: 107 start-page: 85 year: 1999 ident: 10.3945/ajcn.111.025924_bib3 article-title: Cellular adhesion molecules and atherogenesis publication-title: Am J Med doi: 10.1016/S0002-9343(99)00153-9 – volume: 96 start-page: 239 year: 1999 ident: 10.3945/ajcn.111.025924_bib31 article-title: Effect of supplementation with dietary seal oil on selected cardiovascular risk factors and hemostatic variables in healthy male subjects publication-title: Thromb Res doi: 10.1016/S0049-3848(99)00106-1 – volume: 142 start-page: 166 year: 1995 ident: 10.3945/ajcn.111.025924_bib9 article-title: Fish consumption and cardiovascular disease in the physicians’ health study: a prospective study publication-title: Am J Epidemiol doi: 10.1093/oxfordjournals.aje.a117615 – volume: 174 start-page: 127 year: 2004 ident: 10.3945/ajcn.111.025924_bib19 article-title: The effect of diet enriched with α-linolenic acid on soluble cellular adhesion molecules in dyslipidaemic patients publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2004.01.013 – volume: 58 start-page: 2047 year: 2011 ident: 10.3945/ajcn.111.025924_bib39 article-title: Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2011.06.063 – volume: 41 start-page: 760 year: 2009 ident: 10.3945/ajcn.111.025924_bib28 article-title: Effect of fish oil (n-3 polyunsaturated fatty acids) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy: a randomized, double-blind, placebo- controlled study publication-title: Scand J Infect Dis doi: 10.1080/00365540903168056 – volume: 35 start-page: 52 year: 2005 ident: 10.3945/ajcn.111.025924_bib24 article-title: Dietary intake of differently fed salmon; the influence on markers of human atherosclerosis publication-title: Eur J Clin Invest doi: 10.1111/j.1365-2362.2005.01443.x – volume: 36 start-page: 1183 year: 2001 ident: 10.3945/ajcn.111.025924_bib12 article-title: Influence of dietary supplementation with long-chain n-3 or n–6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy individuals publication-title: Lipids doi: 10.1007/s11745-001-0831-4 – ident: 10.3945/ajcn.111.025924_bib16 doi: 10.1042/cs1000091 – volume: 19 start-page: 1681 year: 1999 ident: 10.3945/ajcn.111.025924_bib25 article-title: The effect of supplementation with omega-3 fatty acids on soluble markers of endothelial function in patients with coronary heart disease publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.19.7.1681 – volume: 56 start-page: 45 year: 2010 ident: 10.3945/ajcn.111.025924_bib26 article-title: Effects of marine n-3 fatty acids on circulating levels of soluble adhesion molecules in patients with chronic heart failure publication-title: Cell Mol Biol (Noisy-le-grand) – volume: 206 start-page: 569 year: 2009 ident: 10.3945/ajcn.111.025924_bib18 article-title: Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2009.03.006 – volume: 15 start-page: 622 year: 1995 ident: 10.3945/ajcn.111.025924_bib36 article-title: Docosahexaenoic acid selectively attenuates induction of vascular cell adhesion molecule-1 and subsequent monocytic adhesion to human endothelial cells stimulated by tumor necrosis factor-alpha publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.15.5.622 – volume: 14 start-page: 180 year: 2004 ident: 10.3945/ajcn.111.025924_bib11 article-title: Soluble adhesion molecules in healthy subjects: a dose-response study using n-3 fatty acids publication-title: Nutr Metab Cardiovasc Dis doi: 10.1016/S0939-4753(04)80002-4 – volume: 61 start-page: 349 year: 2001 ident: 10.3945/ajcn.111.025924_bib33 article-title: Lack of effect of fish oil supplementation on coagulation and transcapillary escape rate of albumin in insulin-dependent diabetic patients with diabetic nephropathy publication-title: Scand J Clin Lab Invest doi: 10.1080/003655101316911387 – volume: 81 start-page: 583 year: 2005 ident: 10.3945/ajcn.111.025924_bib15 article-title: Influence of long-term intervention with dietary counseling, long-chain n-3 fatty acid supplements, or both on circulating markers of endothelial activation in men with long-standing hyperlipidemia publication-title: Am J Clin Nutr doi: 10.1093/ajcn/81.3.583 |
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| Title | Effects of n-3 PUFA supplementation on plasma soluble adhesion molecules: a meta-analysis of randomized controlled trials |
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