Dose-Response of a Norovirus GII.2 Controlled Human Challenge Model Inoculum

• Published in: The Journal of infectious diseases Vol. 226; no. 10; pp. 1771 - 1780
• Main Authors: Rouphael, Nadine, Beck, Allison, Kirby, Amy E, Liu, Pengbo, Natrajan, Muktha S, Lai, Lilin, Phadke, Varun, Winston, Juton, Raabe, Vanessa, Collins, Matthew H, Girmay, Tigisty, Alvarez, Alicarmen, Beydoun, Nour, Karmali, Vinit, Altieri-Rivera, Joanne, Lindesmith, Lisa C, Anderson, Evan J, Wang, Yuke, El-Khorazaty, Jill, Petrie, Carey, Baric, Ralph S, Baqar, Shahida, Moe, Christine L, Mulligan, Mark J
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 11.11.2022
• Subjects: Adult; Blood groups; Caliciviridae Infections; Clinical trials; Diarrhea; Gastroenteritis; Genotype; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulins; Infections; Inoculum; Major; Norovirus; Norovirus - genetics; Seroconversion; viral gastroenteritis; ID; Snow Mountain virus; norovirus; infectious dose; human challenge; ID50

Abstract Background Genogroup II noroviruses are the most common cause of acute infectious gastroenteritis. We evaluated the use of a new GII.2 inoculum in a human challenge. Methods Forty-four healthy adults (36 secretor-positive and 8 secretor-negative for histo-blood group antigens) were challeng...