Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their species-specific excretion

• Published in: Environmental research Vol. 99; no. 2; pp. 253 - 261
• Main Authors: Harada, Kouji, Inoue, Kayoko, Morikawa, Akiko, Yoshinaga, Takeo, Saito, Norimitsu, Koizumi, Akio
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.10.2005; Elsevier
• Subjects: Adult; Age Factors; Aged; Alkanesulfonic Acids - blood; Alkanesulfonic Acids - metabolism; Animals; Biological and medical sciences; Caprylates - blood; Caprylates - metabolism; Chemical and industrial products toxicology. Toxic occupational diseases; Environmental Monitoring; Environmental Pollutants - blood; Environmental Pollutants - metabolism; Female; Fluorocarbons - blood; Fluorocarbons - metabolism; Humans; Japan; Kidney - metabolism; Macaca; Macaca fascicularis; Male; Medical sciences; Middle Aged; Models, Biological; Perfluorooctane sulfonate; Perfluorooctanoate; Rats; Rats, Wistar; Renal clearance; Serum; Species Specificity; Toxicology; Urine; Various organic compounds; Urine; Serum; Perfluorooctane sulfonate; Renal clearance; Perfluorooctanoate; Human; Toxicokinetics; Excretion; Urinary system; Organic perhalocompound; Elimination; Sex; Clearance; Age; Kidney; Public health

Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are detected in the environment, as well as more specifically in wildlife and humans. However, the toxicokinetic aspects of perfluorochemicals in humans are unclear. In this study, we measured concentrations of PFOA and PFOS in subjects...