Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their species-specific excretion
Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are detected in the environment, as well as more specifically in wildlife and humans. However, the toxicokinetic aspects of perfluorochemicals in humans are unclear. In this study, we measured concentrations of PFOA and PFOS in subjects...
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| Published in | Environmental research Vol. 99; no. 2; pp. 253 - 261 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier Inc
01.10.2005
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are detected in the environment, as well as more specifically in wildlife and humans. However, the toxicokinetic aspects of perfluorochemicals in humans are unclear. In this study, we measured concentrations of PFOA and PFOS in subjects who had lived in Kyoto city for more than 10 years. The serum concentrations of PFOA and PFOS were higher in females who menstruated than those who did not menstruation (
P
<
0.01
), but in males this did not change by age; the levels in females reached those in males at an age of ⩾60 years. We then determined the renal clearances of PFOA and PFOS in young (20–40 years old,
N
=
5
for each sex) and old (⩾60 years old,
N
=
5
for each sex) subjects of both sexes. All young females were menstruating, while all old females were not. The renal clearances were 10
−5-fold smaller than the glomerular filtration rate in humans, suggesting the absence of active excretion in human kidneys. The renal clearances of PFOA and PFOS were approximately one-fifth of the total clearance based on their serum half-lives, assuming a one-compartment model. The sex differences in renal clearance that have been reported in rats and Japanese macaques were not found in our human subjects. We tried to build a one-compartment pharmacokinetic model using the reported half-lives in human. The model was simple but could predict the serum concentrations in both males and females fairly well. We therefore suggest that an internal dose approach using a pharmacokinetic model should be taken because of the large species differences in kinetics that exist for PFOA and PFOS. |
|---|---|
| AbstractList | Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are detected in the environment, as well as more specifically in wildlife and humans. However, the toxicokinetic aspects of perfluorochemicals in humans are unclear. In this study, we measured concentrations of PFOA and PFOS in subjects who had lived in Kyoto city for more than 10 years. The serum concentrations of PFOA and PFOS were higher in females who menstruated than those who did not menstruation (
P
<
0.01
), but in males this did not change by age; the levels in females reached those in males at an age of ⩾60 years. We then determined the renal clearances of PFOA and PFOS in young (20–40 years old,
N
=
5
for each sex) and old (⩾60 years old,
N
=
5
for each sex) subjects of both sexes. All young females were menstruating, while all old females were not. The renal clearances were 10
−5-fold smaller than the glomerular filtration rate in humans, suggesting the absence of active excretion in human kidneys. The renal clearances of PFOA and PFOS were approximately one-fifth of the total clearance based on their serum half-lives, assuming a one-compartment model. The sex differences in renal clearance that have been reported in rats and Japanese macaques were not found in our human subjects. We tried to build a one-compartment pharmacokinetic model using the reported half-lives in human. The model was simple but could predict the serum concentrations in both males and females fairly well. We therefore suggest that an internal dose approach using a pharmacokinetic model should be taken because of the large species differences in kinetics that exist for PFOA and PFOS. Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are detected in the environment, as well as more specifically in wildlife and humans. However, the toxicokinetic aspects of perfluorochemicals in humans are unclear. In this study, we measured concentrations of PFOA and PFOS in subjects who had lived in Kyoto city for more than 10 years. The serum concentrations of PFOA and PFOS were higher in females who menstruated than those who did not menstruation (P<0.01), but in males this did not change by age; the levels in females reached those in males at an age of >=60 years. We then determined the renal clearances of PFOA and PFOS in young (20-40 years old, N=5 for each sex) and old (>=60 years old, N=5 for each sex) subjects of both sexes. All young females were menstruating, while all old females were not. The renal clearances were 10 super(-) super(5)-fold smaller than the glomerular filtration rate in humans, suggesting the absence of active excretion in human kidneys. The renal clearances of PFOA and PFOS were approximately one-fifth of the total clearance based on their serum half-lives, assuming a one-compartment model. The sex differences in renal clearance that have been reported in rats and Japanese macaques were not found in our human subjects. We tried to build a one-compartment pharmacokinetic model using the reported half-lives in human. The model was simple but could predict the serum concentrations in both males and females fairly well. We therefore suggest that an internal dose approach using a pharmacokinetic model should be taken because of the large species differences in kinetics that exist for PFOA and PFOS. Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are detected in the environment, as well as more specifically in wildlife and humans. However, the toxicokinetic aspects of perfluorochemicals in humans are unclear. In this study, we measured concentrations of PFOA and PFOS in subjects who had lived in Kyoto city for more than 10 years. The serum concentrations of PFOA and PFOS were higher in females who menstruated than those who did not menstruation (P<0.01), but in males this did not change by age; the levels in females reached those in males at an age of 60 years. We then determined the renal clearances of PFOA and PFOS in young (20-40 years old, N=5 for each sex) and old (60 years old, N=5 for each sex) subjects of both sexes. All young females were menstruating, while all old females were not. The renal clearances were 10(-5)-fold smaller than the glomerular filtration rate in humans, suggesting the absence of active excretion in human kidneys. The renal clearances of PFOA and PFOS were approximately one-fifth of the total clearance based on their serum half-lives, assuming a one-compartment model. The sex differences in renal clearance that have been reported in rats and Japanese macaques were not found in our human subjects. We tried to build a one-compartment pharmacokinetic model using the reported half-lives in human. The model was simple but could predict the serum concentrations in both males and females fairly well. We therefore suggest that an internal dose approach using a pharmacokinetic model should be taken because of the large species differences in kinetics that exist for PFOA and PFOS.Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are detected in the environment, as well as more specifically in wildlife and humans. However, the toxicokinetic aspects of perfluorochemicals in humans are unclear. In this study, we measured concentrations of PFOA and PFOS in subjects who had lived in Kyoto city for more than 10 years. The serum concentrations of PFOA and PFOS were higher in females who menstruated than those who did not menstruation (P<0.01), but in males this did not change by age; the levels in females reached those in males at an age of 60 years. We then determined the renal clearances of PFOA and PFOS in young (20-40 years old, N=5 for each sex) and old (60 years old, N=5 for each sex) subjects of both sexes. All young females were menstruating, while all old females were not. The renal clearances were 10(-5)-fold smaller than the glomerular filtration rate in humans, suggesting the absence of active excretion in human kidneys. The renal clearances of PFOA and PFOS were approximately one-fifth of the total clearance based on their serum half-lives, assuming a one-compartment model. The sex differences in renal clearance that have been reported in rats and Japanese macaques were not found in our human subjects. We tried to build a one-compartment pharmacokinetic model using the reported half-lives in human. The model was simple but could predict the serum concentrations in both males and females fairly well. We therefore suggest that an internal dose approach using a pharmacokinetic model should be taken because of the large species differences in kinetics that exist for PFOA and PFOS. Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are detected in the environment, as well as more specifically in wildlife and humans. However, the toxicokinetic aspects of perfluorochemicals in humans are unclear. In this study, we measured concentrations of PFOA and PFOS in subjects who had lived in Kyoto city for more than 10 years. The serum concentrations of PFOA and PFOS were higher in females who menstruated than those who did not menstruation (P<0.01), but in males this did not change by age; the levels in females reached those in males at an age of 60 years. We then determined the renal clearances of PFOA and PFOS in young (20-40 years old, N=5 for each sex) and old (60 years old, N=5 for each sex) subjects of both sexes. All young females were menstruating, while all old females were not. The renal clearances were 10(-5)-fold smaller than the glomerular filtration rate in humans, suggesting the absence of active excretion in human kidneys. The renal clearances of PFOA and PFOS were approximately one-fifth of the total clearance based on their serum half-lives, assuming a one-compartment model. The sex differences in renal clearance that have been reported in rats and Japanese macaques were not found in our human subjects. We tried to build a one-compartment pharmacokinetic model using the reported half-lives in human. The model was simple but could predict the serum concentrations in both males and females fairly well. We therefore suggest that an internal dose approach using a pharmacokinetic model should be taken because of the large species differences in kinetics that exist for PFOA and PFOS. |
| Author | Morikawa, Akiko Saito, Norimitsu Yoshinaga, Takeo Harada, Kouji Koizumi, Akio Inoue, Kayoko |
| Author_xml | – sequence: 1 givenname: Kouji surname: Harada fullname: Harada, Kouji organization: Department of Health and Environmental Sciences, Kyoto University, Graduate School of Medicine, Yoshida Konoecho, Kyoto 606-8501, Japan – sequence: 2 givenname: Kayoko surname: Inoue fullname: Inoue, Kayoko organization: Department of Health and Environmental Sciences, Kyoto University, Graduate School of Medicine, Yoshida Konoecho, Kyoto 606-8501, Japan – sequence: 3 givenname: Akiko surname: Morikawa fullname: Morikawa, Akiko organization: Department of Health and Environmental Sciences, Kyoto University, Graduate School of Medicine, Yoshida Konoecho, Kyoto 606-8501, Japan – sequence: 4 givenname: Takeo surname: Yoshinaga fullname: Yoshinaga, Takeo organization: Department of Health and Environmental Sciences, Kyoto University, Graduate School of Medicine, Yoshida Konoecho, Kyoto 606-8501, Japan – sequence: 5 givenname: Norimitsu surname: Saito fullname: Saito, Norimitsu organization: Research Institute for Environmental Sciences and Public Health of Iwate Prefecture, Morioka, Iwate, Japan – sequence: 6 givenname: Akio surname: Koizumi fullname: Koizumi, Akio email: koizumi@pbh.med.kyoto-u.ac.jp organization: Department of Health and Environmental Sciences, Kyoto University, Graduate School of Medicine, Yoshida Konoecho, Kyoto 606-8501, Japan |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17205932$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/16194675$$D View this record in MEDLINE/PubMed |
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| Keywords | Urine Serum Perfluorooctane sulfonate Renal clearance Perfluorooctanoate Human Toxicokinetics Excretion Urinary system Organic perhalocompound Elimination Sex Clearance Age Kidney Public health |
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| SubjectTerms | Adult Age Factors Aged Alkanesulfonic Acids - blood Alkanesulfonic Acids - metabolism Animals Biological and medical sciences Caprylates - blood Caprylates - metabolism Chemical and industrial products toxicology. Toxic occupational diseases Environmental Monitoring Environmental Pollutants - blood Environmental Pollutants - metabolism Female Fluorocarbons - blood Fluorocarbons - metabolism Humans Japan Kidney - metabolism Macaca Macaca fascicularis Male Medical sciences Middle Aged Models, Biological Perfluorooctane sulfonate Perfluorooctanoate Rats Rats, Wistar Renal clearance Serum Species Specificity Toxicology Urine Various organic compounds |
| Title | Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their species-specific excretion |
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