Phosphorylation of disordered proteins tunes local and global intramolecular interactions

• Published in: Biophysical journal Vol. 123; no. 23; pp. 4082 - 4096
• Main Authors: Usher, Emery T., Fossat, Martin J., Holehouse, Alex S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.12.2024; The Biophysical Society
• Subjects: Intrinsically Disordered Proteins - chemistry; Intrinsically Disordered Proteins - metabolism; Molecular Dynamics Simulation; Monte Carlo Method; Phosphorylation; Phosphoserine - chemistry; Phosphoserine - metabolism

Protein post-translational modifications, such as phosphorylation, are important regulatory signals for diverse cellular functions. In particular, intrinsically disordered protein regions (IDRs) are subject to phosphorylation as a means to modulate their interactions and functions. Toward understand...