Identification and molecular cloning of a functional GDP-fucose transporter in Drosophila melanogaster

• Published in: Experimental cell research Vol. 301; no. 2; pp. 242 - 250
• Main Authors: Lühn, Kerstin, Laskowska, Anna, Pielage, Jan, Klämbt, Christian, Ipe, Ute, Vestweber, Dietmar, Wild, Martin K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.12.2004
• Subjects: Animals; Base Sequence; Cloning, Molecular; Drosophila melanogaster; Drosophila Proteins - chemistry; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Fibroblasts - metabolism; Fibroblasts - ultrastructure; Fucose - metabolism; Fucosylation; GDP-fucose transporter; Gene Components; Genetic Therapy; Golgi Apparatus - metabolism; Humans; Leukocyte adhesion deficiency II (LADII); Leukocyte-Adhesion Deficiency Syndrome - pathology; Leukocyte-Adhesion Deficiency Syndrome - therapy; Monosaccharide Transport Proteins - chemistry; Monosaccharide Transport Proteins - genetics; Monosaccharide Transport Proteins - metabolism; Protein Conformation; Protein Transport; Transfection; GDP-fuc-Tp; UEA; LADII; Leukocyte adhesion deficiency II (LADII); Fucosylation; LTA; GDP-fucose transporter; AAL; Drosophila melanogaster; PSA

Nucleotide sugar transporters play a central role in the process of glycosylation. They are responsible for the translocation of nucleotide sugars from the cytosol, their site of synthesis, into the Golgi apparatus where the activated sugars serve as substrates for a variety of glycosyltransferases....