Lowering Mutant Huntingtin Levels and Toxicity: Autophagy-Endolysosome Pathways in Huntington's Disease

• Published in: Journal of molecular biology Vol. 432; no. 8; pp. 2673 - 2691
• Main Authors: Valionyte, Evelina, Yang, Yi, Roberts, Sheridan L., Kelly, Jack, Lu, Boxun, Luo, Shouqing
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 03.04.2020
• Subjects: Animals; Autophagy; Humans; Huntingtin; Huntingtin Protein - deficiency; Huntington Disease - metabolism; Huntington Disease - pathology; Huntington's disease; Lysosomes - metabolism; Lysosomes - pathology; mutants; Neurodegeneration; neurodegenerative diseases; Selective autophagy; toxicity; Huntingtin; ALS; HTT; mHTT; CK2; Autophagy; SNARE; TBK1; PI3K; Neurodegeneration; shRNA; UBA; mTOR; UPS; polyQ; ULK1/2; AD; Tollip; ASOs; TFEB; siRNA; Huntington's disease; ER; ATG; LIR; PE; STX-17; ROS; Selective autophagy; LAMP; HD; OPTN; PB1

Huntington's disease (HD) is a monogenetic neurodegenerative disease, which serves as a model of neurodegeneration with protein aggregation. Autophagy has been suggested to possess a great value to tackle protein aggregation toxicity and neurodegenerative diseases. Current studies suggest that...