Differences in Influenza-Specific CD4 T-Cell Mediated Immunity Following Acute Infection Versus Inactivated Vaccination in Children

• Published in: The Journal of infectious diseases Vol. 223; no. 12; pp. 2164 - 2173
• Main Authors: Shannon, Ian, White, Chantelle L, Yang, Hongmei, Nayak, Jennifer L
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 15.06.2021
• Subjects: Age; CD4 antigen; CD4-Positive T-Lymphocytes - immunology; Child; Child, Preschool; Children; Clinical trials; Humans; Immune imprinting; Immune response; Immune system; Immunity, Cellular; Immunocompetence; Immunologic Memory; Immunological memory; Infections; Influenza; Influenza A Virus, H3N2 Subtype; Influenza Vaccines - immunology; Influenza, Human - prevention & control; Lymphocytes T; Major and Brief Reports; Pediatrics; Vaccination; Vaccines, Inactivated - immunology; γ-Interferon; cellular immune response; CD4 T cells; influenza immunity; pediatrics

Abstract Background Early childhood influenza infections imprint influenza-specific immune memory, with most studies evaluating antibody specificity. In this study, we examined how infection versus inactivated influenza vaccination (IIV) establish pediatric CD4 T-cell mediated immunity to influenza...