Effect of oxytocin antagonists on the activation of human myometrium in vitro: Atosiban prevents oxytocin-induced desensitization

• Published in: American journal of obstetrics and gynecology Vol. 171; no. 6; pp. 1627 - 1634
• Main Authors: Phaneuf, S., Asbóth, G., MacKenzie, I.Z., Melin, P., López Bernal, A.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier Inc 01.12.1994; Elsevier
• Subjects: Biological and medical sciences; Calcium - metabolism; Cell receptors; Cell structures and functions; Culture Techniques; Female; Fundamental and applied biological sciences. Psychology; Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors; human myometrium; Humans; inositol phosphates; Inositol Phosphates - biosynthesis; intracellular calcium; Intracellular Membranes - metabolism; Molecular and cellular biology; Myometrium - cytology; Myometrium - drug effects; Myometrium - physiology; Oxytocin - antagonists & inhibitors; Oxytocin - metabolism; Oxytocin antagonists; oxytocin receptors; Time Factors; Vasotocin - analogs & derivatives; Vasotocin - pharmacology; Oxytocin antagonists; human myometrium; intracellular calcium; inositol phosphates; oxytocin receptors; Human; Myometrium; Desensitization; Oxytocin; Peptide hormone; Neuropeptide; In vitro; Prevention; Sensitivity resistance; Neurohypophyseal hormone; Delivery disorders; Antagonist; Hormonal receptor

Objective: Our purpose was to investigate whether the sensitivity of myometrial cells to oxytocin is affected by prolonged exposure to oxytocin antagonists. Study Design: Tissue slices or cultured myometrial cells were exposed to peptides in vitro. Myometrial activation was studied by measuring the...