Minimally invasive insulin delivery in subjects with type 1 diabetes using hollow microneedles

• Published in: Diabetes technology & therapeutics Vol. 11; no. 6; p. 329
• Main Authors: Gupta, Jyoti, Felner, Eric I, Prausnitz, Mark R
• Format: Journal Article
• Language: English
• Published: United States 01.06.2009
• Subjects: Adult; Animals; Blood Glucose - metabolism; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - drug therapy; Female; Glycated Hemoglobin - metabolism; Humans; Injections, Subcutaneous - adverse effects; Injections, Subcutaneous - instrumentation; Injections, Subcutaneous - methods; Insulin - administration & dosage; Insulin - therapeutic use; Insulin Infusion Systems; Male; Microchemistry - instrumentation; Microchemistry - methods; Miniaturization; Pain - etiology; Postprandial Period

Microneedles have previously been used to deliver insulin to animal models, but not in human subjects. This study tested the hypothesis that hollow microneedles can deliver insulin to modulate blood glucose levels in subjects with type 1 diabetes in a minimally invasive manner. This study was carrie...