Maintenance of Miranda Localization in Drosophila Neuroblasts Involves Interaction with the Cognate mRNA

• Published in: Current biology Vol. 27; no. 14; pp. 2101 - 2111.e5
• Main Authors: Ramat, Anne, Hannaford, Matthew, Januschke, Jens
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 24.07.2017; Elsevier; Cell Press
• Subjects: Animals; asymmetric cell division; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Drosophila; Drosophila melanogaster - genetics; Drosophila melanogaster - growth & development; Drosophila melanogaster - physiology; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Female; Larva - genetics; Larva - physiology; Life Sciences; Male; Mitosis; mRNA localization; nanobody; Neural Stem Cells - metabolism; neuroblasts; polarity; RNA, Messenger - genetics; RNA, Messenger - metabolism; mRNA localization; asymmetric cell division; nanobody; Drosophila; neuroblasts; polarity

How cells position their proteins is a key problem in cell biology. Targeting mRNAs to distinct regions of the cytoplasm contributes to protein localization by providing local control over translation. Here, we reveal that an interdependence of a protein and cognate mRNA maintains asymmetric protein...