The role of amyloid-beta in the regulation of memory

• Published in: Biochemical pharmacology Vol. 88; no. 4; pp. 479 - 485
• Main Authors: Morley, John E., Farr, Susan A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 15.04.2014
• Subjects: Amyloid beta-Peptides - biosynthesis; Amyloid beta-Peptides - physiology; Amyloid-beta; Animals; Blood brain barrier; Memory - physiology; Memory enhancer; Mice; Mitochondria - physiology; Mitochondrial; Peptide; Plaque, Amyloid; Memory enhancer; Mitochondrial; Peptide; Blood brain barrier; Amyloid-beta

In this review there is evidence that amyloid-beta peptide is a memory enhancer at physiological (picomolar) concentrations. Pathological overproduction of amyloid-beta leads to impaired memory, oxidative damage, damage to the blood brain barrier, neurofibrillary tangles and amyloid plaque formation...