Eradication of Rickettsia tsutsugamushi from patients' blood by chemotherapy, as assessed by the polymerase chain reaction

• Published in: The American journal of tropical medicine and hygiene Vol. 52; no. 4; p. 325
• Main Authors: Murai, K, Okayama, A, Horinouchi, H, Oshikawa, T, Tachibana, N, Tsubouchi, H
• Format: Journal Article
• Language: English
• Published: United States 01.04.1995
• Subjects: Aged; Aged, 80 and over; Antibodies, Bacterial - blood; Base Sequence; DNA Primers - chemistry; DNA, Bacterial - blood; DNA, Bacterial - chemistry; Doxycycline - therapeutic use; Electrophoresis, Agar Gel; Female; Fluorescent Antibody Technique; Humans; Leukocytes, Mononuclear - microbiology; Male; Middle Aged; Minocycline - therapeutic use; Molecular Sequence Data; Orientia tsutsugamushi - genetics; Orientia tsutsugamushi - immunology; Orientia tsutsugamushi - isolation & purification; Polymerase Chain Reaction; Scrub Typhus - drug therapy; Scrub Typhus - microbiology

The presence of Rickettsia tsutsugamushi DNA in peripheral blood mononuclear cells of eight patients with tsutsugamushi disease was determined by the polymerase chain reaction during antibiotic treatment with minocycline or doxycycline. Rickettsia tsutsugamushi DNA was detectable in all samples from...