The Role Of PD-1/PD-L1 Axis In Treg Development And Function: Implications For Cancer Immunotherapy

• Published in: OncoTargets and therapy Vol. 12; pp. 8437 - 8445
• Main Authors: Cai, Jiajing, Wang, Dongsheng, Zhang, Guoyuan, Guo, Xiaolan
• Format: Journal Article
• Language: English
• Published: Macclesfield Taylor & Francis Ltd 01.01.2019; Dove
• Subjects: Apoptosis; Cancer; Cancer immunotherapy; Cancer therapies; Cell growth; Immune checkpoint; Immunotherapy; Laboratories; Lymphocytes; Lymphocytes T; Medical schools; Medicine; Melanoma; PD-1 protein; PD-L1 protein; Review; China

During the past decade, immunotherapy targeting immune checkpoints has become an important component of the treatment paradigm for numerous malignancies, especially PD-1/PD-L1 blockade which was demonstrated to rejuvenate disabled T cells in cancer patients to achieve long-term remissions. However,...