Overexpression of GOLPH3 Promotes Proliferation and Tumorigenicity in Breast Cancer via Suppression of the FOXO1 Transcription Factor

• Published in: Clinical cancer research Vol. 18; no. 15; pp. 4059 - 4069
• Main Authors: Zeng, Zhaolei, Lin, Huanxin, Zhao, Xiaohui, Liu, Guanglin, Wang, Xi, Xu, Ruihua, Chen, Kun, Li, Jun, Song, Libing
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.08.2012
• Subjects: Animals; Antineoplastic agents; Biological and medical sciences; Blotting, Western; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Cycle - genetics; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - metabolism; Cyclin-Dependent Kinase Inhibitor Proteins - genetics; Cyclin-Dependent Kinase Inhibitor Proteins - metabolism; Female; Forkhead Box Protein O1; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Gene Expression Regulation, Neoplastic; Gynecology. Andrology. Obstetrics; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Ki-67 Antigen - metabolism; Mammary gland diseases; Medical sciences; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Pharmacology. Drug treatments; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transplantation, Heterologous; Tumors; Cell proliferation; Mammary gland diseases; Breast disease; Toxicity; Gene overexpression; Breast cancer; Tumorigenicity; Malignant tumor; Transcription factor FOXO1; Cancer

Purpose: Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in various biologic processes. The clinical significance and biologic role of GOLPH3 in breast cancer, however, remains unknown. Experimental Design: Expression of GOLPH3 in normal breast cells, breast cancer cells, and 6-pair...