Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet-fed mice

• Published in: Science translational medicine Vol. 8; no. 357; p. 357ra122
• Main Authors: Rao, Anuradha, Kosters, Astrid, Mells, Jamie E, Zhang, Wujuan, Setchell, Kenneth D R, Amanso, Angelica M, Wynn, Grace M, Xu, Tianlei, Keller, Brad T, Yin, Hong, Banton, Sophia, Jones, Dean P, Wu, Hao, Dawson, Paul A, Karpen, Saul J
• Format: Journal Article
• Language: English
• Published: United States 21.09.2016
• Subjects: Animals; Bile Acids and Salts - metabolism; Ceramides - metabolism; Cholesterol - metabolism; Cyclic N-Oxides - administration & dosage; Cyclic N-Oxides - pharmacology; Diet, High-Fat - adverse effects; Feces; Gene Expression Regulation - drug effects; Glucose Tolerance Test; Ileum - drug effects; Ileum - metabolism; Liver - drug effects; Liver - metabolism; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease - pathology; Non-alcoholic Fatty Liver Disease - prevention & control; Organic Anion Transporters, Sodium-Dependent - deficiency; Organic Anion Transporters, Sodium-Dependent - metabolism; Receptors, Cytoplasmic and Nuclear - agonists; Receptors, Cytoplasmic and Nuclear - metabolism; Symporters - deficiency; Symporters - metabolism; Triglycerides - metabolism; Tropanes - administration & dosage; Tropanes - pharmacology

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the Western world, and safe and effective therapies are needed. Bile acids (BAs) and their receptors [including the nuclear receptor for BAs, farnesoid X receptor (FXR)] play integral roles in regulating whole-body...