A Metabolomic Aging Clock Using Human Cerebrospinal Fluid

• Published in: The journals of gerontology. Series A, Biological sciences and medical sciences Vol. 77; no. 4; p. 744
• Main Authors: Hwangbo, Nathan, Zhang, Xinyu, Raftery, Daniel, Gu, Haiwei, Hu, Shu-Ching, Montine, Thomas J, Quinn, Joseph F, Chung, Kathryn A, Hiller, Amie L, Wang, Dongfang, Fei, Qiang, Bettcher, Lisa, Zabetian, Cyrus P, Peskind, Elaine, Li, Gail, Promislow, Daniel E L, Franks, Alexander
• Format: Journal Article
• Language: English
• Published: United States 01.04.2022
• Subjects: Aging; Biomarkers - cerebrospinal fluid; Cohort Studies; Humans; Mass Spectrometry; Metabolome; Metabolomics - methods; Metabolomics; Aging clock; Biomarker; Cerebrospinal fluid

Quantifying the physiology of aging is essential for improving our understanding of age-related disease and the heterogeneity of healthy aging. Recent studies have shown that, in regression models using "-omic" platforms to predict chronological age, residual variation in predicted age is...