Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice

• Published in: The journals of gerontology. Series A, Biological sciences and medical sciences Vol. 76; no. 11; p. 1895
• Main Authors: Saccon, Tatiana Dandolini, Nagpal, Ravinder, Yadav, Hariom, Cavalcante, Marcelo Borges, Nunes, Allancer Divino de Carvalho, Schneider, Augusto, Gesing, Adam, Hughes, Brian, Yousefzadeh, Matthew, Tchkonia, Tamar, Kirkland, James L, Niedernhofer, Laura J, Robbins, Paul D, Masternak, Michal M
• Format: Journal Article
• Language: English
• Published: United States 01.11.2021
• Subjects: Animals; Biomarkers; Cellular Senescence - drug effects; Dasatinib - pharmacology; Gastrointestinal Microbiome; Inflammation - drug therapy; Interleukin-6; Intestines; Mice; Quercetin - pharmacology; Senotherapeutics; Tumor Necrosis Factor-alpha; Microbiota; Longevity; Biology of aging; Cellular senescence; Microbiome

Cellular senescence contributes to age-related disorders including physical dysfunction, disabilities, and mortality caused by tissue inflammation and damage. Senescent cells accumulate in multiple tissues with aging and at etiological sites of multiple chronic disorders. The senolytic drug combinat...