Rational biosynthetic approaches for the production of new-to-nature compounds in fungi

• Published in: Fungal genetics and biology Vol. 89; pp. 89 - 101
• Main Authors: Boecker, Simon, Zobel, Sophia, Meyer, Vera, Süssmuth, Roderich D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2016
• Subjects: Aspergillus; Aspergillus - genetics; Aspergillus - metabolism; Biological Products; Combinatorial biosynthesis; Depsipeptides - isolation & purification; Drug Discovery - methods; Fungi - genetics; Fungi - metabolism; Metabolic engineering; Metabolic Engineering - methods; Mutasynthesis; Precursor-directed biosynthesis; Secondary metabolite; Combinatorial biosynthesis; Precursor-directed biosynthesis; Aspergillus; Metabolic engineering; Secondary metabolite; Mutasynthesis

[Display omitted] •Fungal secondary metabolites are a rich source for drug development.•Extension of fungal natural product portfolio by generation of non-natural compounds.•Description of past and recent strategies for fungal natural product diversification.•Covering examples from current state-of-...