Detection of nonneutral substitution rates on mammalian phylogenies

• Published in: Genome research Vol. 20; no. 1; pp. 110 - 121
• Main Authors: Pollard, Katherine S., Hubisz, Melissa J., Rosenbloom, Kate R., Siepel, Adam
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.01.2010
• Subjects: Animals; Base Sequence; Computer Simulation; Conserved Sequence; Evolution, Molecular; Humans; Likelihood Functions; Mammals - classification; Mammals - genetics; Methods; Models, Genetic; Models, Statistical; Phylogeny; Primates - genetics; Selection, Genetic; Sequence Alignment; Software; Species Specificity
• ISSN: 1088-9051; 1549-5469; 1549-5469
• DOI: 10.1101/gr.097857.109

Methods for detecting nucleotide substitution rates that are faster or slower than expected under neutral drift are widely used to identify candidate functional elements in genomic sequences. However, most existing methods consider either reductions (conservation) or increases (acceleration) in rate...