Distribution and subcellular localization of a water-soluble hematoporphyrin–platinum(II) complex in human bladder cancer cells

The water-soluble porphyrin–platinum complex diammine{7,12-bis[1-(polyethyleneglycol-750-monomethylether-1-yl)ethyl]-3,8,13,17-tetramethylporphyrin-2,18-dipropionato}platinum(II) (PEG-HPPt) was studied with respect to cellular accumulation, subcellular localization, behavior in 3D-cell aggregates an...

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Published inCancer letters Vol. 215; no. 2; pp. 167 - 177
Main Authors Lottner, Christian, Knuechel, Ruth, Bernhardt, Guenther, Brunner, Henri
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 25.11.2004
Elsevier Limited
Subjects
Antineoplastic Agents - metabolism
Antineoplastic Agents - therapeutic use
Bladder cancer
Cancer therapies
Cell Line
Cell Line, Tumor
Chemotherapy
Cytotoxicity
Deoxyribonucleic acid
DNA
DNA, Neoplasm - metabolism
Drug Screening Assays, Antitumor
Hematoporphyrins - metabolism
Hematoporphyrins - therapeutic use
Humans
Organoplatinum Compounds - chemistry
Organoplatinum Compounds - metabolism
Organoplatinum Compounds - therapeutic use
Photodynamic therapy
Photosensitizing Agents - metabolism
Photosensitizing Agents - therapeutic use
Platinum
Platinum - metabolism
Porphyrins - chemistry
Porphyrins - therapeutic use
Porphyrin–platinum complex
Proteins
Selective accumulation
Spheroids, Cellular
Tissue Distribution
Tumors
Urinary Bladder - metabolism
Urinary Bladder Neoplasms - drug therapy
Urinary Bladder Neoplasms - metabolism
Germany
PDT
Chemotherapy
Photodynamic therapy
PEG
Selective accumulation
M-VAC
DMF
Porphyrin–platinum complex
Bladder cancer
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Abstract The water-soluble porphyrin–platinum complex diammine{7,12-bis[1-(polyethyleneglycol-750-monomethylether-1-yl)ethyl]-3,8,13,17-tetramethylporphyrin-2,18-dipropionato}platinum(II) (PEG-HPPt) was studied with respect to cellular accumulation, subcellular localization, behavior in 3D-cell aggregates and degree of DNA platination on the low-differentiated J82 cells, a model of invasive bladder cancer, and UROtsa, a normal urothelial cell line. Accumulation studies with 2D and spheroid cell cultures revealed that the concentration of PEG-HPPt was 1.7-times higher in J82 cancer cells than in UROtsa cells. Despite its high molecular weight, penetration of PEG-HPPt was not restricted to the peripheral cells of the spheroids. Fluorescence microscopic analysis showed that PEG-HPPt was localized in essential cellular targets of photodynamic therapy. DNA platination in J82 and UROtsa cells was higher by PEG-HPPt than by cisplatin, whereas there was no significant difference between the two cell lines.
AbstractList The water-soluble porphyrin–platinum complex diammine{7,12-bis[1-(polyethyleneglycol-750-monomethylether-1-yl)ethyl]-3,8,13,17-tetramethylporphyrin-2,18-dipropionato}platinum(II) (PEG-HPPt) was studied with respect to cellular accumulation, subcellular localization, behavior in 3D-cell aggregates and degree of DNA platination on the low-differentiated J82 cells, a model of invasive bladder cancer, and UROtsa, a normal urothelial cell line. Accumulation studies with 2D and spheroid cell cultures revealed that the concentration of PEG-HPPt was 1.7-times higher in J82 cancer cells than in UROtsa cells. Despite its high molecular weight, penetration of PEG-HPPt was not restricted to the peripheral cells of the spheroids. Fluorescence microscopic analysis showed that PEG-HPPt was localized in essential cellular targets of photodynamic therapy. DNA platination in J82 and UROtsa cells was higher by PEG-HPPt than by cisplatin, whereas there was no significant difference between the two cell lines.
Author Knuechel, Ruth
Bernhardt, Guenther
Brunner, Henri
Lottner, Christian
Author_xml – sequence: 1
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  surname: Brunner
  fullname: Brunner, Henri
  organization: Institute of Inorganic Chemistry, University of Regensburg, 93040 Regensburg, Germany
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Cites_doi 10.2307/3579816
10.1016/0003-2697(68)90092-4
10.1002/(SICI)1097-0215(19970304)70:5<551::AID-IJC10>3.0.CO;2-G
10.1002/1097-0215(20010601)92:5<671::AID-IJC1240>3.0.CO;2-P
10.1021/bi00413a022
10.1111/j.1432-1033.1973.tb02881.x
10.1007/BF00686402
10.1002/(SICI)1521-4184(19996)332:6<195::AID-ARDP195>3.0.CO;2-H
10.1016/S1011-1344(96)07428-3
10.1172/JCI115080
10.1016/1011-1344(95)07275-6
10.1021/j150642a027
10.1016/0076-6879(87)52008-0
10.1126/science.2581316
10.1007/BF02784549
10.1002/lsm.1900170103
10.1016/0006-2952(94)90132-5
10.1016/S0020-1693(97)05593-X
10.1111/j.1751-1097.1991.tb03669.x
10.1002/jpp.328
10.1097/00001813-199308000-00011
10.1016/j.canlet.2003.09.001
10.1136/bmj.300.6719.230
10.1111/j.1751-1097.1993.tb09218.x
10.1038/bjc.1997.450
10.1021/jm0110688
10.1038/bjc.1995.135
10.1016/1011-1344(90)85088-E
10.1016/0959-8049(94)90301-8
10.1054/bjoc.2001.1977
10.1002/(SICI)1096-9101(1998)22:1<14::AID-LSM6>3.0.CO;2-#
10.1007/BF00698738
10.1111/j.1751-1097.1997.tb08581.x
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Keywords PDT
Chemotherapy
Photodynamic therapy
PEG
Selective accumulation
M-VAC
DMF
Porphyrin–platinum complex
Bladder cancer
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References Brunner, Schellerer, Treittinger (bib1) 1997; 264
Kunz-Schughart, Müller-Klieser (bib19) 2000
Bernhardt, Koch, Spruß, Gust, Krauser, Schlemmer (bib24) 1999; 332
Ochsner (bib6) 1997; 47
O'Toole (bib11) 1986; vol. IV
Lottner, Bart, Bernhardt, Brunner (bib2) 2002; 45
Wallace (bib22) 1987; 152
Reile, Bernhardt, Koch, Schönenberger, Hollstein, Lux (bib14) 1992; 30
Bigelow, Mitra, Knuechel, Foster (bib20) 2001; 85
C. Lottner, PhD thesis, University of Regensburg, 2003.
Gross-Bellard, Oudet, Chembon (bib21) 1973; 36
Matthews, Altman, Campbell, Royston (bib26) 1990; 300
Köberle, Grimaldi, Sunters, Hartley, Kelland, Masters (bib44) 1997; 70
Kessel, Luo, Deng, Chang (bib30) 1997; 65
Sedlak, Lindsay (bib25) 1968; 25
Shellard, Fichtinger-Schepman, Lazo, Hill (bib38) 1993; 4
Hasan (bib8) 1992
Hill, Scanlon, Hansson, Harstrick, Pera, Fichtinger-Schepman, Shellard (bib41) 1994; 30
Parker, Eastman, Bostick-Bruton, Reed (bib43) 1991; 87
Ochsner (bib28) 1997; 39
R.F. Boyer, Modern experimental biochemistry Benjamin/Cummings Publish, Menlo Park1986 pp. 437–446, 479–488.
Sark, Timmer-Bosscha, Meijer, Uges, Sluiter, Peters (bib39) 1995; 71
Wyld, Burn, Reed, Brown (bib13) 1997; 76
Lee, Rodgers (bib32) 1983; 87
Liang, Shin, Lee, Nguyen, Trang, Pan (bib31) 1998; 22
Krieg, Fickweiler, Messmann, Knuechel (bib15) 1999
Bedford, Fichtinger-Schepman, Shellard, Walker, Masters, Hill (bib40) 1988; 48
He, Sassa, Lim (bib12) 1993; 57
Lipsky, Pagano (bib17) 1985; 228
Szeimies, Karrer, Abels, Steinbach, Fickweiler, Messmann (bib16) 1996; 34
Eastman (bib35) 1999
Lottner, Knuechel, Bernhardt, Brunner (bib3) 2004; 203
Lux, Hollstein, Reile, Bernhardt, Schönenberger (bib36) 1996; 53
MacDonald, Dougherty (bib34) 2001; 5
Jocham, Baumgartner, Stepp, Unsold (bib4) 1990; 6
Fisher, Murphree, Gomer (bib7) 1995; 17
Moan, Berg (bib33) 1991; 53
Hamblin, Miller, Rizvi, Ortel, Maytin, Hasan (bib9) 2001; 61
Prinsze, Penning, Dubbelmann, VanSteveninck (bib5) 1992; 52
Petzoldt, Leigh, Duffy, Sexton, Masters (bib10) 1995; 23
Oleinick, Evans (bib29) 1998; 150
Johnson, Perez, Godwin, Yeung, Handel, Ozols, Hamilton (bib37) 1994; 47
Seidl, Rauch, Krieg, Appel, Baumgartner, Knuechel (bib18) 2001; 92
Eastman, Schulte (bib42) 1988; 27
Kessel (10.1016/j.canlet.2004.06.035_bib30) 1997; 65
Sark (10.1016/j.canlet.2004.06.035_bib39) 1995; 71
Eastman (10.1016/j.canlet.2004.06.035_bib35) 1999
Jocham (10.1016/j.canlet.2004.06.035_bib4) 1990; 6
Hasan (10.1016/j.canlet.2004.06.035_bib8) 1992
Ochsner (10.1016/j.canlet.2004.06.035_bib6) 1997; 47
He (10.1016/j.canlet.2004.06.035_bib12) 1993; 57
Lipsky (10.1016/j.canlet.2004.06.035_bib17) 1985; 228
Eastman (10.1016/j.canlet.2004.06.035_bib42) 1988; 27
Krieg (10.1016/j.canlet.2004.06.035_bib15) 1999
Gross-Bellard (10.1016/j.canlet.2004.06.035_bib21) 1973; 36
Petzoldt (10.1016/j.canlet.2004.06.035_bib10) 1995; 23
MacDonald (10.1016/j.canlet.2004.06.035_bib34) 2001; 5
Köberle (10.1016/j.canlet.2004.06.035_bib44) 1997; 70
Hamblin (10.1016/j.canlet.2004.06.035_bib9) 2001; 61
10.1016/j.canlet.2004.06.035_bib27
Shellard (10.1016/j.canlet.2004.06.035_bib38) 1993; 4
10.1016/j.canlet.2004.06.035_bib23
Bedford (10.1016/j.canlet.2004.06.035_bib40) 1988; 48
Liang (10.1016/j.canlet.2004.06.035_bib31) 1998; 22
Wyld (10.1016/j.canlet.2004.06.035_bib13) 1997; 76
O'Toole (10.1016/j.canlet.2004.06.035_bib11) 1986; vol. IV
Brunner (10.1016/j.canlet.2004.06.035_bib1) 1997; 264
Bigelow (10.1016/j.canlet.2004.06.035_bib20) 2001; 85
Ochsner (10.1016/j.canlet.2004.06.035_bib28) 1997; 39
Hill (10.1016/j.canlet.2004.06.035_bib41) 1994; 30
Reile (10.1016/j.canlet.2004.06.035_bib14) 1992; 30
Wallace (10.1016/j.canlet.2004.06.035_bib22) 1987; 152
Lottner (10.1016/j.canlet.2004.06.035_bib2) 2002; 45
Lux (10.1016/j.canlet.2004.06.035_bib36) 1996; 53
Moan (10.1016/j.canlet.2004.06.035_bib33) 1991; 53
Lottner (10.1016/j.canlet.2004.06.035_bib3) 2004; 203
Johnson (10.1016/j.canlet.2004.06.035_bib37) 1994; 47
Kunz-Schughart (10.1016/j.canlet.2004.06.035_bib19) 2000
Parker (10.1016/j.canlet.2004.06.035_bib43) 1991; 87
Oleinick (10.1016/j.canlet.2004.06.035_bib29) 1998; 150
Bernhardt (10.1016/j.canlet.2004.06.035_bib24) 1999; 332
Seidl (10.1016/j.canlet.2004.06.035_bib18) 2001; 92
Prinsze (10.1016/j.canlet.2004.06.035_bib5) 1992; 52
Lee (10.1016/j.canlet.2004.06.035_bib32) 1983; 87
Fisher (10.1016/j.canlet.2004.06.035_bib7) 1995; 17
Szeimies (10.1016/j.canlet.2004.06.035_bib16) 1996; 34
Matthews (10.1016/j.canlet.2004.06.035_bib26) 1990; 300
Sedlak (10.1016/j.canlet.2004.06.035_bib25) 1968; 25
References_xml – volume: 53
  start-page: 113
  year: 1996
  end-page: 128
  ident: bib36
  article-title: Discrepancy between cytotoxicity, platinum accumulation, and DNA platination in MCF-7 breast cancer cells treated with diaqua(1,2-diphenylethylenediamine)platinum(II) sulfates and cisplatin, Biol
  publication-title: Trace Elem. Res.
  contributor:
    fullname: Schönenberger
– volume: 264
  start-page: 67
  year: 1997
  end-page: 79
  ident: bib1
  article-title: Synthesis and in vitro testing of hematoporphyrin type ligands in platinum(II) complexes as potent cytostatic and phototoxic antitumor agents
  publication-title: Inorg. Chim. Acta
  contributor:
    fullname: Treittinger
– volume: 92
  start-page: 671
  year: 2001
  end-page: 677
  ident: bib18
  article-title: Optimization of differential photodynamic effectiveness between normal and tumor urothelial cells using 5-aminolevulinic acid-induced protoporphyrin IX as sensitizer
  publication-title: Int. J. Cancer
  contributor:
    fullname: Knuechel
– volume: 23
  start-page: 377
  year: 1995
  end-page: 380
  ident: bib10
  article-title: Immortalisation of human urothelial cells
  publication-title: Urol. Res.
  contributor:
    fullname: Masters
– volume: 85
  start-page: 727
  year: 2001
  end-page: 734
  ident: bib20
  article-title: ALA- and ALA-hexylester-induced protoporphyrin IX fluorescence and distribution in multicell tumour spheroids
  publication-title: Br. J. Cancer
  contributor:
    fullname: Foster
– volume: 228
  start-page: 745
  year: 1985
  end-page: 747
  ident: bib17
  article-title: A vital stain for the Golgi apparatus
  publication-title: Science
  contributor:
    fullname: Pagano
– volume: 87
  start-page: 4894
  year: 1983
  end-page: 4898
  ident: bib32
  article-title: Singlet molecular oxygen in micellar systems. 1. Distribution equilibriums between hydrophobic and hydrophilic compartments
  publication-title: J. Phys. Chem.
  contributor:
    fullname: Rodgers
– volume: 52
  start-page: 117
  year: 1992
  end-page: 120
  ident: bib5
  article-title: Interaction of photodynamic treatment and either hyperthermia or ionizing radiation and of ionizing radiation and hyperthermia with respect to cell killing of L929 fibroblasts, Chinese hamster ovary cells, and T24 human bladder carcinoma cells
  publication-title: Cancer Res.
  contributor:
    fullname: VanSteveninck
– volume: 150
  start-page: 146
  year: 1998
  end-page: 156
  ident: bib29
  article-title: The photobiology of photodynamic therapy: cellular targets and mechanisms
  publication-title: Radiat. Res.
  contributor:
    fullname: Evans
– volume: 45
  start-page: 2064
  year: 2002
  end-page: 2078
  ident: bib2
  article-title: Hematoporphyrin-derived soluble porphyrin-platinum conjugates with combined cytotoxic and phototoxic antitumor activity
  publication-title: J. Med. Chem.
  contributor:
    fullname: Brunner
– start-page: 111
  year: 1999
  end-page: 134
  ident: bib35
  article-title: The mechanism of action of cisplatin: from adducts to apoptosis
  publication-title: Cisplatin: chemistry and biochemistry of a leading anticancer drug
  contributor:
    fullname: Eastman
– volume: 47
  start-page: 689
  year: 1994
  end-page: 697
  ident: bib37
  article-title: Role of platinum-DNA adduct formation and removal in cisplatin resistance in human ovarian cancer cell lines
  publication-title: Biochem. Pharmacol.
  contributor:
    fullname: Hamilton
– volume: 25
  start-page: 192
  year: 1968
  end-page: 205
  ident: bib25
  article-title: Estimation of total, protein-bound, and non-protein sulfhydryl groups in tissue with Ellman's reagent
  publication-title: Anal. Biochem.
  contributor:
    fullname: Lindsay
– volume: 4
  start-page: 491
  year: 1993
  end-page: 500
  ident: bib38
  article-title: Evidence of differential cisplatin-DNA adduct formation, removal and tolerance of DNA damage in three human lung carcinoma cell lines
  publication-title: Anticancer Drugs
  contributor:
    fullname: Hill
– volume: 71
  start-page: 684
  year: 1995
  end-page: 690
  ident: bib39
  article-title: Cellular basis for differential sensitivity to cisplatin in human germ cell tumour and colon carcinoma cell lines
  publication-title: Br. J. Cancer
  contributor:
    fullname: Peters
– volume: 6
  start-page: 183
  year: 1990
  end-page: 187
  ident: bib4
  article-title: Clinical experience with the integral photodynamic therapy of bladder carcinoma
  publication-title: J. Photochem. Photobiol. B Biol.
  contributor:
    fullname: Unsold
– start-page: 187
  year: 1992
  end-page: 200
  ident: bib8
  article-title: Photosensitizer delivery mediated by macromolecular carrier systems
  publication-title: Photodynamic Therapy: Basic Principles and Clinical Applications
  contributor:
    fullname: Hasan
– volume: 70
  start-page: 551
  year: 1997
  end-page: 555
  ident: bib44
  article-title: DNA repair capacity and cisplatin sensitivity of human testis tumour cells
  publication-title: Int. J. Cancer
  contributor:
    fullname: Masters
– volume: 47
  start-page: 1185
  year: 1997
  end-page: 1194
  ident: bib6
  article-title: Photodynamic therapy: the clinical perspective. Review on applications for control of diverse tumorous and non-tumorous diseases
  publication-title: Drug Res.
  contributor:
    fullname: Ochsner
– volume: 53
  start-page: 549
  year: 1991
  end-page: 553
  ident: bib33
  article-title: The photodegradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen
  publication-title: Photochem. Photobiol.
  contributor:
    fullname: Berg
– volume: 30
  start-page: 113
  year: 1992
  end-page: 122
  ident: bib14
  article-title: Chemosensitivity of human MCF-7 breast cancer cells to diastereoisomeric diaqua(1,2-diphenylethylenediamine)platinum(II) sulfates and specific platinum accumulation
  publication-title: Cancer Chemother. Pharmacol.
  contributor:
    fullname: Lux
– volume: 30
  start-page: 832
  year: 1994
  end-page: 837
  ident: bib41
  article-title: Deficient repair of cisplatin-DNA adducts identified in human testicular teratoma cell lines established from tumours from untreated patients
  publication-title: Eur. J. Cancer
  contributor:
    fullname: Shellard
– volume: 36
  start-page: 32
  year: 1973
  end-page: 38
  ident: bib21
  article-title: Isolation of high-molecular-weight DNA from mammalian cells
  publication-title: Eur. J. Biochem.
  contributor:
    fullname: Chembon
– volume: 152
  start-page: 41
  year: 1987
  end-page: 48
  ident: bib22
  article-title: Precipitation of nucleic acids
  publication-title: Methods Enzymol.
  contributor:
    fullname: Wallace
– volume: 61
  start-page: 7155
  year: 2001
  end-page: 7162
  ident: bib9
  article-title: Pegylation of a chlorin(e6) polymer conjugate increases tumor targeting of photosensitizer
  publication-title: Cancer Res.
  contributor:
    fullname: Hasan
– volume: vol. IV
  start-page: 103
  year: 1986
  end-page: 125
  ident: bib11
  article-title: Human bladder cancer cell lines: HLA Class I and Class II antigen expression and susceptibility to cytostatic and cytolytic effects in vitro
  publication-title: In vitro Models for Cancer Research
  contributor:
    fullname: O'Toole
– volume: 27
  start-page: 4730
  year: 1988
  end-page: 4734
  ident: bib42
  article-title: Enhanced DNA repair as a mechanism of resistance to
  publication-title: Biochemistry
  contributor:
    fullname: Schulte
– volume: 76
  start-page: 705
  year: 1997
  end-page: 712
  ident: bib13
  article-title: Factors affecting aminolaevulinic acid-induced generation of protoporphyrin IX
  publication-title: Br. J. Cancer
  contributor:
    fullname: Brown
– volume: 17
  start-page: 2
  year: 1995
  end-page: 31
  ident: bib7
  article-title: Clinical and preclinical photodynamic therapy
  publication-title: Lasers Surg. Med.
  contributor:
    fullname: Gomer
– volume: 57
  start-page: 825
  year: 1993
  end-page: 829
  ident: bib12
  article-title: Effect of UVA and blue light on porphyrin biosynthesis on epidermal cells
  publication-title: Photochem. Photobiol.
  contributor:
    fullname: Lim
– volume: 65
  start-page: 422
  year: 1997
  end-page: 426
  ident: bib30
  article-title: The role of subcellular localization in initiation of apoptosis by photodynamic therapy
  publication-title: Photochem. Photobiol.
  contributor:
    fullname: Chang
– start-page: 301
  year: 1999
  end-page: 309
  ident: bib15
  article-title: The role of intracellular distribution of 5-aminolevulinic acid (ALA) induced protoporphyrin IX (PPIX) for efficacy of photodynamic therapy
  publication-title: Fluorescent Microscopy and Fluorescent Probes 3
  contributor:
    fullname: Knuechel
– volume: 300
  start-page: 230
  year: 1990
  end-page: 235
  ident: bib26
  article-title: Analysis of serial measurements in medical research
  publication-title: Br. Med. J.
  contributor:
    fullname: Royston
– volume: 5
  start-page: 105
  year: 2001
  end-page: 129
  ident: bib34
  article-title: Basic principles of photodynamic therapy
  publication-title: J. Porphyrins Phthalocyanines
  contributor:
    fullname: Dougherty
– volume: 34
  start-page: 67
  year: 1996
  end-page: 72
  ident: bib16
  article-title: 9-Acetoxy-2,7,12,17-tetrakis-(beta-methoxyethyl)-porphycene (ATMPn), a novel photosensitizer for photodynamic therapy: uptake kinetics and intracellular localization
  publication-title: J. Photochem. Photobiol. B Biol.
  contributor:
    fullname: Messmann
– volume: 22
  start-page: 14
  year: 1998
  end-page: 24
  ident: bib31
  article-title: Subcellular phototoxicity of 5-aminolaevulinic acid (ALA)
  publication-title: Lasers Surg. Med.
  contributor:
    fullname: Pan
– volume: 87
  start-page: 772
  year: 1991
  end-page: 777
  ident: bib43
  article-title: Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation
  publication-title: J. Clin. Invest.
  contributor:
    fullname: Reed
– volume: 203
  start-page: 171
  year: 2004
  end-page: 180
  ident: bib3
  article-title: Combined chemotherapeutic and photodynamic treatment on human bladder cells by hematoporphyrin-platinum(II) conjugates
  publication-title: Cancer Lett.
  contributor:
    fullname: Brunner
– volume: 39
  start-page: 1
  year: 1997
  end-page: 18
  ident: bib28
  article-title: Photophysical and photobiological processes in the photodynamic therapy of tumours
  publication-title: J. Photochem. Photobiol. B Biol.
  contributor:
    fullname: Ochsner
– start-page: 123
  year: 2000
  end-page: 148
  ident: bib19
  article-title: Three-dimensional culture
  publication-title: Animal Cell Culture–A Practical Approach
  contributor:
    fullname: Müller-Klieser
– volume: 332
  start-page: 195
  year: 1999
  end-page: 200
  ident: bib24
  article-title: meso-1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]sulfatoplatinum(II)-pharmacokinetic studies, Arch
  publication-title: Pharm. Pharm. Med. Chem.
  contributor:
    fullname: Schlemmer
– volume: 48
  start-page: 3019
  year: 1988
  end-page: 3024
  ident: bib40
  article-title: Differential repair of platinum-DNA adducts in human bladder and testicular tumor continuous cell lines
  publication-title: Cancer Res.
  contributor:
    fullname: Hill
– volume: 150
  start-page: 146
  year: 1998
  ident: 10.1016/j.canlet.2004.06.035_bib29
  article-title: The photobiology of photodynamic therapy: cellular targets and mechanisms
  publication-title: Radiat. Res.
  doi: 10.2307/3579816
  contributor:
    fullname: Oleinick
– volume: 25
  start-page: 192
  year: 1968
  ident: 10.1016/j.canlet.2004.06.035_bib25
  article-title: Estimation of total, protein-bound, and non-protein sulfhydryl groups in tissue with Ellman's reagent
  publication-title: Anal. Biochem.
  doi: 10.1016/0003-2697(68)90092-4
  contributor:
    fullname: Sedlak
– volume: 70
  start-page: 551
  year: 1997
  ident: 10.1016/j.canlet.2004.06.035_bib44
  article-title: DNA repair capacity and cisplatin sensitivity of human testis tumour cells
  publication-title: Int. J. Cancer
  doi: 10.1002/(SICI)1097-0215(19970304)70:5<551::AID-IJC10>3.0.CO;2-G
  contributor:
    fullname: Köberle
– start-page: 111
  year: 1999
  ident: 10.1016/j.canlet.2004.06.035_bib35
  article-title: The mechanism of action of cisplatin: from adducts to apoptosis
  contributor:
    fullname: Eastman
– volume: 92
  start-page: 671
  year: 2001
  ident: 10.1016/j.canlet.2004.06.035_bib18
  article-title: Optimization of differential photodynamic effectiveness between normal and tumor urothelial cells using 5-aminolevulinic acid-induced protoporphyrin IX as sensitizer
  publication-title: Int. J. Cancer
  doi: 10.1002/1097-0215(20010601)92:5<671::AID-IJC1240>3.0.CO;2-P
  contributor:
    fullname: Seidl
– start-page: 301
  year: 1999
  ident: 10.1016/j.canlet.2004.06.035_bib15
  article-title: The role of intracellular distribution of 5-aminolevulinic acid (ALA) induced protoporphyrin IX (PPIX) for efficacy of photodynamic therapy
  contributor:
    fullname: Krieg
– volume: 27
  start-page: 4730
  year: 1988
  ident: 10.1016/j.canlet.2004.06.035_bib42
  article-title: Enhanced DNA repair as a mechanism of resistance to cis-diamminedichloroplatinum(II)
  publication-title: Biochemistry
  doi: 10.1021/bi00413a022
  contributor:
    fullname: Eastman
– start-page: 123
  year: 2000
  ident: 10.1016/j.canlet.2004.06.035_bib19
  article-title: Three-dimensional culture
  contributor:
    fullname: Kunz-Schughart
– volume: 52
  start-page: 117
  year: 1992
  ident: 10.1016/j.canlet.2004.06.035_bib5
  article-title: Interaction of photodynamic treatment and either hyperthermia or ionizing radiation and of ionizing radiation and hyperthermia with respect to cell killing of L929 fibroblasts, Chinese hamster ovary cells, and T24 human bladder carcinoma cells
  publication-title: Cancer Res.
  contributor:
    fullname: Prinsze
– volume: vol. IV
  start-page: 103
  year: 1986
  ident: 10.1016/j.canlet.2004.06.035_bib11
  article-title: Human bladder cancer cell lines: HLA Class I and Class II antigen expression and susceptibility to cytostatic and cytolytic effects in vitro
  contributor:
    fullname: O'Toole
– volume: 36
  start-page: 32
  year: 1973
  ident: 10.1016/j.canlet.2004.06.035_bib21
  article-title: Isolation of high-molecular-weight DNA from mammalian cells
  publication-title: Eur. J. Biochem.
  doi: 10.1111/j.1432-1033.1973.tb02881.x
  contributor:
    fullname: Gross-Bellard
– volume: 48
  start-page: 3019
  year: 1988
  ident: 10.1016/j.canlet.2004.06.035_bib40
  article-title: Differential repair of platinum-DNA adducts in human bladder and testicular tumor continuous cell lines
  publication-title: Cancer Res.
  contributor:
    fullname: Bedford
– volume: 30
  start-page: 113
  year: 1992
  ident: 10.1016/j.canlet.2004.06.035_bib14
  article-title: Chemosensitivity of human MCF-7 breast cancer cells to diastereoisomeric diaqua(1,2-diphenylethylenediamine)platinum(II) sulfates and specific platinum accumulation
  publication-title: Cancer Chemother. Pharmacol.
  doi: 10.1007/BF00686402
  contributor:
    fullname: Reile
– volume: 332
  start-page: 195
  year: 1999
  ident: 10.1016/j.canlet.2004.06.035_bib24
  article-title: meso-1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]sulfatoplatinum(II)-pharmacokinetic studies, Arch
  publication-title: Pharm. Pharm. Med. Chem.
  doi: 10.1002/(SICI)1521-4184(19996)332:6<195::AID-ARDP195>3.0.CO;2-H
  contributor:
    fullname: Bernhardt
– volume: 39
  start-page: 1
  year: 1997
  ident: 10.1016/j.canlet.2004.06.035_bib28
  article-title: Photophysical and photobiological processes in the photodynamic therapy of tumours
  publication-title: J. Photochem. Photobiol. B Biol.
  doi: 10.1016/S1011-1344(96)07428-3
  contributor:
    fullname: Ochsner
– volume: 87
  start-page: 772
  year: 1991
  ident: 10.1016/j.canlet.2004.06.035_bib43
  article-title: Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI115080
  contributor:
    fullname: Parker
– volume: 34
  start-page: 67
  year: 1996
  ident: 10.1016/j.canlet.2004.06.035_bib16
  article-title: 9-Acetoxy-2,7,12,17-tetrakis-(beta-methoxyethyl)-porphycene (ATMPn), a novel photosensitizer for photodynamic therapy: uptake kinetics and intracellular localization
  publication-title: J. Photochem. Photobiol. B Biol.
  doi: 10.1016/1011-1344(95)07275-6
  contributor:
    fullname: Szeimies
– volume: 87
  start-page: 4894
  year: 1983
  ident: 10.1016/j.canlet.2004.06.035_bib32
  article-title: Singlet molecular oxygen in micellar systems. 1. Distribution equilibriums between hydrophobic and hydrophilic compartments
  publication-title: J. Phys. Chem.
  doi: 10.1021/j150642a027
  contributor:
    fullname: Lee
– volume: 152
  start-page: 41
  year: 1987
  ident: 10.1016/j.canlet.2004.06.035_bib22
  article-title: Precipitation of nucleic acids
  publication-title: Methods Enzymol.
  doi: 10.1016/0076-6879(87)52008-0
  contributor:
    fullname: Wallace
– volume: 228
  start-page: 745
  year: 1985
  ident: 10.1016/j.canlet.2004.06.035_bib17
  article-title: A vital stain for the Golgi apparatus
  publication-title: Science
  doi: 10.1126/science.2581316
  contributor:
    fullname: Lipsky
– volume: 53
  start-page: 113
  year: 1996
  ident: 10.1016/j.canlet.2004.06.035_bib36
  article-title: Discrepancy between cytotoxicity, platinum accumulation, and DNA platination in MCF-7 breast cancer cells treated with diaqua(1,2-diphenylethylenediamine)platinum(II) sulfates and cisplatin, Biol
  publication-title: Trace Elem. Res.
  doi: 10.1007/BF02784549
  contributor:
    fullname: Lux
– volume: 17
  start-page: 2
  year: 1995
  ident: 10.1016/j.canlet.2004.06.035_bib7
  article-title: Clinical and preclinical photodynamic therapy
  publication-title: Lasers Surg. Med.
  doi: 10.1002/lsm.1900170103
  contributor:
    fullname: Fisher
– start-page: 187
  year: 1992
  ident: 10.1016/j.canlet.2004.06.035_bib8
  article-title: Photosensitizer delivery mediated by macromolecular carrier systems
  contributor:
    fullname: Hasan
– volume: 47
  start-page: 689
  year: 1994
  ident: 10.1016/j.canlet.2004.06.035_bib37
  article-title: Role of platinum-DNA adduct formation and removal in cisplatin resistance in human ovarian cancer cell lines
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/0006-2952(94)90132-5
  contributor:
    fullname: Johnson
– volume: 264
  start-page: 67
  year: 1997
  ident: 10.1016/j.canlet.2004.06.035_bib1
  article-title: Synthesis and in vitro testing of hematoporphyrin type ligands in platinum(II) complexes as potent cytostatic and phototoxic antitumor agents
  publication-title: Inorg. Chim. Acta
  doi: 10.1016/S0020-1693(97)05593-X
  contributor:
    fullname: Brunner
– volume: 53
  start-page: 549
  year: 1991
  ident: 10.1016/j.canlet.2004.06.035_bib33
  article-title: The photodegradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen
  publication-title: Photochem. Photobiol.
  doi: 10.1111/j.1751-1097.1991.tb03669.x
  contributor:
    fullname: Moan
– volume: 5
  start-page: 105
  year: 2001
  ident: 10.1016/j.canlet.2004.06.035_bib34
  article-title: Basic principles of photodynamic therapy
  publication-title: J. Porphyrins Phthalocyanines
  doi: 10.1002/jpp.328
  contributor:
    fullname: MacDonald
– volume: 4
  start-page: 491
  year: 1993
  ident: 10.1016/j.canlet.2004.06.035_bib38
  article-title: Evidence of differential cisplatin-DNA adduct formation, removal and tolerance of DNA damage in three human lung carcinoma cell lines
  publication-title: Anticancer Drugs
  doi: 10.1097/00001813-199308000-00011
  contributor:
    fullname: Shellard
– volume: 203
  start-page: 171
  year: 2004
  ident: 10.1016/j.canlet.2004.06.035_bib3
  article-title: Combined chemotherapeutic and photodynamic treatment on human bladder cells by hematoporphyrin-platinum(II) conjugates
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2003.09.001
  contributor:
    fullname: Lottner
– volume: 300
  start-page: 230
  year: 1990
  ident: 10.1016/j.canlet.2004.06.035_bib26
  article-title: Analysis of serial measurements in medical research
  publication-title: Br. Med. J.
  doi: 10.1136/bmj.300.6719.230
  contributor:
    fullname: Matthews
– ident: 10.1016/j.canlet.2004.06.035_bib23
– volume: 57
  start-page: 825
  year: 1993
  ident: 10.1016/j.canlet.2004.06.035_bib12
  article-title: Effect of UVA and blue light on porphyrin biosynthesis on epidermal cells
  publication-title: Photochem. Photobiol.
  doi: 10.1111/j.1751-1097.1993.tb09218.x
  contributor:
    fullname: He
– ident: 10.1016/j.canlet.2004.06.035_bib27
– volume: 76
  start-page: 705
  year: 1997
  ident: 10.1016/j.canlet.2004.06.035_bib13
  article-title: Factors affecting aminolaevulinic acid-induced generation of protoporphyrin IX
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.1997.450
  contributor:
    fullname: Wyld
– volume: 45
  start-page: 2064
  year: 2002
  ident: 10.1016/j.canlet.2004.06.035_bib2
  article-title: Hematoporphyrin-derived soluble porphyrin-platinum conjugates with combined cytotoxic and phototoxic antitumor activity
  publication-title: J. Med. Chem.
  doi: 10.1021/jm0110688
  contributor:
    fullname: Lottner
– volume: 47
  start-page: 1185
  year: 1997
  ident: 10.1016/j.canlet.2004.06.035_bib6
  article-title: Photodynamic therapy: the clinical perspective. Review on applications for control of diverse tumorous and non-tumorous diseases
  publication-title: Drug Res.
  contributor:
    fullname: Ochsner
– volume: 71
  start-page: 684
  year: 1995
  ident: 10.1016/j.canlet.2004.06.035_bib39
  article-title: Cellular basis for differential sensitivity to cisplatin in human germ cell tumour and colon carcinoma cell lines
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.1995.135
  contributor:
    fullname: Sark
– volume: 6
  start-page: 183
  year: 1990
  ident: 10.1016/j.canlet.2004.06.035_bib4
  article-title: Clinical experience with the integral photodynamic therapy of bladder carcinoma
  publication-title: J. Photochem. Photobiol. B Biol.
  doi: 10.1016/1011-1344(90)85088-E
  contributor:
    fullname: Jocham
– volume: 30
  start-page: 832
  year: 1994
  ident: 10.1016/j.canlet.2004.06.035_bib41
  article-title: Deficient repair of cisplatin-DNA adducts identified in human testicular teratoma cell lines established from tumours from untreated patients
  publication-title: Eur. J. Cancer
  doi: 10.1016/0959-8049(94)90301-8
  contributor:
    fullname: Hill
– volume: 85
  start-page: 727
  year: 2001
  ident: 10.1016/j.canlet.2004.06.035_bib20
  article-title: ALA- and ALA-hexylester-induced protoporphyrin IX fluorescence and distribution in multicell tumour spheroids
  publication-title: Br. J. Cancer
  doi: 10.1054/bjoc.2001.1977
  contributor:
    fullname: Bigelow
– volume: 61
  start-page: 7155
  year: 2001
  ident: 10.1016/j.canlet.2004.06.035_bib9
  article-title: Pegylation of a chlorin(e6) polymer conjugate increases tumor targeting of photosensitizer
  publication-title: Cancer Res.
  contributor:
    fullname: Hamblin
– volume: 22
  start-page: 14
  year: 1998
  ident: 10.1016/j.canlet.2004.06.035_bib31
  article-title: Subcellular phototoxicity of 5-aminolaevulinic acid (ALA)
  publication-title: Lasers Surg. Med.
  doi: 10.1002/(SICI)1096-9101(1998)22:1<14::AID-LSM6>3.0.CO;2-#
  contributor:
    fullname: Liang
– volume: 23
  start-page: 377
  year: 1995
  ident: 10.1016/j.canlet.2004.06.035_bib10
  article-title: Immortalisation of human urothelial cells
  publication-title: Urol. Res.
  doi: 10.1007/BF00698738
  contributor:
    fullname: Petzoldt
– volume: 65
  start-page: 422
  year: 1997
  ident: 10.1016/j.canlet.2004.06.035_bib30
  article-title: The role of subcellular localization in initiation of apoptosis by photodynamic therapy
  publication-title: Photochem. Photobiol.
  doi: 10.1111/j.1751-1097.1997.tb08581.x
  contributor:
    fullname: Kessel
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Snippet The water-soluble porphyrin–platinum complex...
The water-soluble porphyrin-platinum complex...
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SubjectTerms Antineoplastic Agents - metabolism
Antineoplastic Agents - therapeutic use
Bladder cancer
Cancer therapies
Cell Line
Cell Line, Tumor
Chemotherapy
Cytotoxicity
Deoxyribonucleic acid
DNA
DNA, Neoplasm - metabolism
Drug Screening Assays, Antitumor
Hematoporphyrins - metabolism
Hematoporphyrins - therapeutic use
Humans
Organoplatinum Compounds - chemistry
Organoplatinum Compounds - metabolism
Organoplatinum Compounds - therapeutic use
Photodynamic therapy
Photosensitizing Agents - metabolism
Photosensitizing Agents - therapeutic use
Platinum
Platinum - metabolism
Porphyrins - chemistry
Porphyrins - therapeutic use
Porphyrin–platinum complex
Proteins
Selective accumulation
Spheroids, Cellular
Tissue Distribution
Tumors
Urinary Bladder - metabolism
Urinary Bladder Neoplasms - drug therapy
Urinary Bladder Neoplasms - metabolism
Title Distribution and subcellular localization of a water-soluble hematoporphyrin–platinum(II) complex in human bladder cancer cells
URI https://dx.doi.org/10.1016/j.canlet.2004.06.035
https://www.ncbi.nlm.nih.gov/pubmed/15488635
https://www.proquest.com/docview/1505368095
https://search.proquest.com/docview/66985877
Volume 215
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