Newton's cradle: Cell cycle regulation by two mutually inhibitory oscillators

• Published in: Mathematical biosciences Vol. 377; pp. 109291 - None
• Main Authors: Dragoi, Calin-Mihai, Tyson, John J., Novák, Béla
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2024; American Elsevier
• Subjects: Animals; Bistability; Cell cycle; Cell Cycle - physiology; Checkpoints; Endocycles; Humans; Models, Biological; Oscillations; Oscillations; Endocycles; Cell cycle; Checkpoints; Bistability

•Two doubly amplified, negative feedback oscillators control the cell division cycle.•They drive alternating phases of chromosome replication and segregation.•Mutual inhibition between the two oscillators is responsible for their alternation.•Arrest of one oscillator may lead to endocycles or to che...