Brain perfusion abnormalities in drug-naive, lactate-sensitive panic patients: A SPECT study

• Published in: Biological psychiatry (1969) Vol. 33; no. 7; pp. 505 - 512
• Main Authors: De Cristofaro, Maria Teresa R., Sessarego, Antonella, Pupi, Alberto, Biondi, Francesco, Faravelli, Carlo
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.1993; Elsevier Science
• Subjects: 99mTc-HMPAO; Adult; Adult and adolescent clinical studies; Anxiety disorders. Neuroses; Biological and medical sciences; Brain - blood supply; Cerebral Cortex - blood supply; Dominance, Cerebral - physiology; drug-naive patients; Female; Humans; Lactates; Lactic Acid; Male; Medical sciences; Organotechnetium Compounds; Oximes; Panic disorder; Panic Disorder - diagnostic imaging; Personality Inventory; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Regional Blood Flow - physiology; regional cerebral blood flow; SPECT; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon; 99mTc-HMPAO; regional cerebral blood flow; drug-naive patients; SPECT; Panic disorder; Radionuclide study; Human; Regional blood flow; Cerebral cortex; Panic; Pathophysiology; Radiodiagnosis; Central nervous system; Anxiety disorder; Photon; Computerized axial tomography; Positron emission tomography; Hippocampus; Brain (vertebrata)

Using single photon emission computed tomography (SPECT) and 99mTc-hexamethylpropyleneamine oxime (HM-PAO), we assessed brain perfusion in seven patients with panic disorder (PD) and in five age-matched normal subjects at rest. No patient had ever received drug treatment for panic. All patients were...