A simple method for rapid screening and diagnosis of common organic acidemias: quantitative detection of serum and urine organic acid profiles based on liquid chromatography-tandem mass spectrometry

• Published in: Analytical and bioanalytical chemistry Vol. 414; no. 27; pp. 7823 - 7837
• Main Authors: Jin, Lizi, Liu, Zhenni, Zeng, Jie, Zhao, Haijian, Zhang, Jiangtao, Zhu, Bo, Zhang, Yu, Zhang, Tianjiao, Zhang, Chuanbao
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2022; Springer; Springer Nature B.V
• Subjects: Analysis; Analytical Chemistry; Biochemistry; blood serum; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Chromatography; Composition; derivatization; detection limit; Diagnosis; Food Science; Isomers; Laboratory Medicine; Liquid chromatography; Liquid-liquid extraction; Mass spectrometry; Mass spectroscopy; Metabolic disorders; Methods; Monitoring/Environmental Analysis; Organic acids; Patients; rapid methods; Research Paper; Scientific imaging; Serum; Spectroscopy; tandem mass spectrometry; Urine; China; Newborn screening; Liquid chromatography-tandem mass spectrometry; Inherited metabolic disorders; Organic acid profiles

Organic acid (OA) analysis is a specific test for inherited metabolic disorders (IMDs); however, the previous detection methods are laborious and costly. This study aims to develop a rapid method for the simultaneous quantification of serum and urine OA profiles. The method was established based on...