COT: an efficient and accurate method for detecting marker genes among many subtypes

• Published in: Bioinformatics advances Vol. 2; no. 1; p. vbac037
• Main Authors: Lu, Yingzhou, Wu, Chiung-Ting, Parker, Sarah J, Cheng, Zuolin, Saylor, Georgia, Van Eyk, Jennifer E, Yu, Guoqiang, Clarke, Robert, Herrington, David M, Wang, Yue
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 2022
• Subjects: Application Note; Bioinformatics; Gene expression; Proteomics

Motivation Ideally, a molecularly distinct subtype would be composed of molecular features that are expressed uniquely in the subtype of interest but in no others—so-called marker genes (MGs). MG plays a critical role in the characterization, classification or deconvolution of tissue or cell subtype...