Do SCFA have a role in appetite regulation?

• Published in: Proceedings of the Nutrition Society Vol. 70; no. 1; pp. 119 - 128
• Main Authors: Darzi, Julia, Frost, Gary S., Robertson, M. Denise
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.02.2011; CABI Pub. on behalf of the Nutrition Society
• Subjects: acetates; adipocytes; appetite; Appetite Regulation; Appetite Regulation - drug effects; Carbohydrates; colon; Colon - metabolism; Colon - microbiology; Dairy products; Dietary Fats; Dietary Fats - metabolism; Dietary Fats - pharmacology; Dietary Fiber; drug effects; energy; Fatty Acids, Volatile; Fatty Acids, Volatile - metabolism; Fatty Acids, Volatile - pharmacology; Fermentation; fructans; Gastrointestinal Hormones; Homeostasis; Human subjects; Humans; ileum; Ingestion; leptin; metabolism; microbiology; Nutrition; palatability; peptide YY; pharmacology; Postgraduate Symposium; Prebiotics; propionic acid; receptors; Rodents; Satiation; Satiation - drug effects; satiety; Studies; Taste; Propionic acid; Inulin; Propionate; Satiety; Acetate; Acetic acid; SCFA; Oligofructose

The recently discovered SCFA-activated G-coupled protein receptors FFA receptor 2 and FFA receptor 3 are co-localised in l-cells with the anorexigenic ‘ileal brake’ gut hormone peptide YY, and also in adipocytes, with activation stimulating leptin release. Thus, SCFA such as acetate and propionate s...