Neurochemical characterization of insulin receptor-expressing primary sensory neurons in wild-type and vanilloid type 1 transient receptor potential receptor knockout mice

• Published in: Journal of comparative neurology (1911) Vol. 503; no. 2; pp. 334 - 347
• Main Authors: Baiou, Djalil, Santha, Peter, Avelino, Antonio, Charrua, Ana, Bacskai, Timea, Matesz, Klara, Cruz, Francisco, Nagy, Istvan
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 10.07.2007
• Subjects: Animals; Calcitonin Gene-Related Peptide; diabetes; dorsal root ganglion; Ganglia, Spinal - cytology; Ganglia, Spinal - metabolism; Immunohistochemistry; Intermediate Filament Proteins - metabolism; Membrane Glycoproteins - metabolism; Mice; Mice, Knockout; Nerve Tissue Proteins - metabolism; Neurofilament Proteins - metabolism; Neurons, Afferent - cytology; Neurons, Afferent - metabolism; pain; Peripherins; Receptor, Insulin - metabolism; Statistics, Nonparametric; Tissue Distribution; TRPV Cation Channels - genetics; TRPV Cation Channels - metabolism

The insulin receptor (IR) is expressed by a subpopulation of primary sensory neurons (PSN), including a proportion of cells expressing the nociceptive transducer vanilloid type 1 transient receptor potential receptor (TRPV1). Recent data suggest functional links between the IR and other receptors, i...