Neuronal Galectin‐4 is required for axon growth and for the organization of axonal membrane L1 delivery and clustering

• Published in: Journal of neurochemistry Vol. 125; no. 1; pp. 49 - 62
• Main Authors: Velasco, Silvia, Díez‐Revuelta, Natalia, Hernández‐Iglesias, Teresa, Kaltner, Herbert, André, Sabine, Gabius, Hans‐Joachim, Abad‐Rodríguez, José
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.04.2013
• Subjects: Animals; axon growth; Axons - metabolism; Axons - ultrastructure; Binding sites; Cells, Cultured; Cerebral Cortex - cytology; galectin; Galectin 4 - genetics; Galectin 4 - metabolism; Gene Knockout Techniques; glycoprotein; Glycoproteins; Hippocampus - cytology; Neural Cell Adhesion Molecule L1 - metabolism; Neurochemistry; neuron; Neurons - metabolism; Neurons - ultrastructure; Plasma; polarity; Rats; Rats, Wistar; RNA, Small Interfering - genetics; sulfatide

Axon membrane glycoproteins are essential for neuronal differentiation, although the mechanisms underlying their polarized sorting and organization are poorly understood. We describe here that galectin‐4 (Gal‐4), a lectin highly expressed in gastrointestinal tissues and involved in epithelial glycop...