OCT4 Spliced Variants Are Differentially Expressed in Human Pluripotent and Nonpluripotent Cells

OCT4 is a master regulator of self‐renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We have examined the expression pattern of these OCT4 isoforms in various human pluripotent and nonpluripotent cells. Our data revealed that whereas OCT4A e...

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Published inStem cells (Dayton, Ohio) Vol. 26; no. 12; pp. 3068 - 3074
Main Authors Atlasi, Yaser, Mowla, Seyed J., Ziaee, Seyed A.M., Gokhale, Paul J., Andrews, Peter W.
Format Journal Article
LanguageEnglish
Published Bristol John Wiley & Sons, Ltd 01.12.2008
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Abstract OCT4 is a master regulator of self‐renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We have examined the expression pattern of these OCT4 isoforms in various human pluripotent and nonpluripotent cells. Our data revealed that whereas OCT4A expression is restricted to embryonic stem (ES) and embryonal carcinoma (EC) cells, OCT4B can be detected in various nonpluripotent cell types. Furthermore, we detected a novel OCT4 spliced variant, designated OCT4B1, that is expressed primarily in human ES and EC cells and is downregulated following their differentiation. We also found a significantly higher level of OCT4B1 expression in stage‐specific embryonic antigen‐3 (SSEA3)(+) compared with SSEA3(−) subpopulations of cultured ES cells. Taken together, our data demonstrated a distinctive expression pattern for OCT4 spliced variants in different cell types and highlight the necessity of defining the type of OCT4 when addressing the expression of this gene in different human cells. Disclosure of potential conflicts of interest is found at the end of this article.
AbstractList OCT4 is a master regulator of self-renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We have examined the expression pattern of these OCT4 isoforms in various human pluripotent and nonpluripotent cells. Our data revealed that whereas OCT4A expression is restricted to embryonic stem (ES) and embryonal carcinoma (EC) cells, OCT4B can be detected in various nonpluripotent cell types. Furthermore, we detected a novel OCT4 spliced variant, designated OCT4B1, that is expressed primarily in human ES and EC cells and is downregulated following their differentiation. We also found a significantly higher level of OCT4B1 expression in stage-specific embryonic antigen-3 (SSEA3)(+) compared with SSEA3(-) subpopulations of cultured ES cells. Taken together, our data demonstrated a distinctive expression pattern for OCT4 spliced variants in different cell types and highlight the necessity of defining the type of OCT4 when addressing the expression of this gene in different human cells.
OCT4 is a master regulator of self-renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We have examined the expression pattern of these OCT4 isoforms in various human pluripotent and nonpluripotent cells. Our data revealed that whereas OCT4A expression is restricted to embryonic stem (ES) and embryonal carcinoma (EC) cells, OCT4B can be detected in various nonpluripotent cell types. Furthermore, we detected a novel OCT4 spliced variant, designated OCT4B1, that is expressed primarily in human ES and EC cells and is downregulated following their differentiation. We also found a significantly higher level of OCT4B1 expression in stage-specific embryonic antigen-3 (SSEA3)(+) compared with SSEA3(-) subpopulations of cultured ES cells. Taken together, our data demonstrated a distinctive expression pattern for OCT4 spliced variants in different cell types and highlight the necessity of defining the type of OCT4 when addressing the expression of this gene in different human cells. Disclosure of potential conflicts of interest is found at the end of this article.
OCT4 is a master regulator of self‐renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We have examined the expression pattern of these OCT4 isoforms in various human pluripotent and nonpluripotent cells. Our data revealed that whereas OCT4A expression is restricted to embryonic stem (ES) and embryonal carcinoma (EC) cells, OCT4B can be detected in various nonpluripotent cell types. Furthermore, we detected a novel OCT4 spliced variant, designated OCT4B1, that is expressed primarily in human ES and EC cells and is downregulated following their differentiation. We also found a significantly higher level of OCT4B1 expression in stage‐specific embryonic antigen‐3 (SSEA3)(+) compared with SSEA3(−) subpopulations of cultured ES cells. Taken together, our data demonstrated a distinctive expression pattern for OCT4 spliced variants in different cell types and highlight the necessity of defining the type of OCT4 when addressing the expression of this gene in different human cells. Disclosure of potential conflicts of interest is found at the end of this article.
Abstract OCT4 is a master regulator of self-renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We have examined the expression pattern of these OCT4 isoforms in various human pluripotent and nonpluripotent cells. Our data revealed that whereas OCT4A expression is restricted to embryonic stem (ES) and embryonal carcinoma (EC) cells, OCT4B can be detected in various nonpluripotent cell types. Furthermore, we detected a novel OCT4 spliced variant, designated OCT4B1, that is expressed primarily in human ES and EC cells and is downregulated following their differentiation. We also found a significantly higher level of OCT4B1 expression in stage-specific embryonic antigen-3 (SSEA3)(+) compared with SSEA3(−) subpopulations of cultured ES cells. Taken together, our data demonstrated a distinctive expression pattern for OCT4 spliced variants in different cell types and highlight the necessity of defining the type of OCT4 when addressing the expression of this gene in different human cells. Disclosure of potential conflicts of interest is found at the end of this article.
Author Mowla, Seyed J.
Atlasi, Yaser
Andrews, Peter W.
Gokhale, Paul J.
Ziaee, Seyed A.M.
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  givenname: Peter W.
  surname: Andrews
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/18787205$$D View this record in MEDLINE/PubMed
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PublicationCentury 2000
PublicationDate December 2008
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  year: 2008
  text: December 2008
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PublicationPlace Bristol
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PublicationTitle Stem cells (Dayton, Ohio)
PublicationTitleAlternate Stem Cells
PublicationYear 2008
Publisher John Wiley & Sons, Ltd
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Snippet OCT4 is a master regulator of self‐renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We have...
OCT4 is a master regulator of self-renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We have...
Abstract OCT4 is a master regulator of self-renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We...
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SubjectTerms Alternative Splicing
Antigens, Tumor-Associated, Carbohydrate - biosynthesis
Cancer
Cell Differentiation
Cell Line, Tumor
Embryonic stem cells
Embryonic Stem Cells - cytology
Exons
Gene Expression Regulation
HeLa Cells
Humans
Introns
K562 Cells
OCT4
OCT4B1
Octamer Transcription Factor-3 - biosynthesis
Octamer Transcription Factor-3 - genetics
Pluripotent Stem Cells - metabolism
Protein Isoforms
Spliced variants
Stage-Specific Embryonic Antigens - biosynthesis
Stem Cells - metabolism
Title OCT4 Spliced Variants Are Differentially Expressed in Human Pluripotent and Nonpluripotent Cells
URI https://onlinelibrary.wiley.com/doi/abs/10.1634%2Fstemcells.2008-0530
https://www.ncbi.nlm.nih.gov/pubmed/18787205
https://search.proquest.com/docview/1540222523
https://search.proquest.com/docview/69908720
Volume 26
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