OCT4 Spliced Variants Are Differentially Expressed in Human Pluripotent and Nonpluripotent Cells
OCT4 is a master regulator of self‐renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We have examined the expression pattern of these OCT4 isoforms in various human pluripotent and nonpluripotent cells. Our data revealed that whereas OCT4A e...
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| Published in | Stem cells (Dayton, Ohio) Vol. 26; no. 12; pp. 3068 - 3074 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Bristol
John Wiley & Sons, Ltd
01.12.2008
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| Subjects | |
| Online Access | Get full text |
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| Abstract | OCT4 is a master regulator of self‐renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We have examined the expression pattern of these OCT4 isoforms in various human pluripotent and nonpluripotent cells. Our data revealed that whereas OCT4A expression is restricted to embryonic stem (ES) and embryonal carcinoma (EC) cells, OCT4B can be detected in various nonpluripotent cell types. Furthermore, we detected a novel OCT4 spliced variant, designated OCT4B1, that is expressed primarily in human ES and EC cells and is downregulated following their differentiation. We also found a significantly higher level of OCT4B1 expression in stage‐specific embryonic antigen‐3 (SSEA3)(+) compared with SSEA3(−) subpopulations of cultured ES cells. Taken together, our data demonstrated a distinctive expression pattern for OCT4 spliced variants in different cell types and highlight the necessity of defining the type of OCT4 when addressing the expression of this gene in different human cells.
Disclosure of potential conflicts of interest is found at the end of this article. |
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| AbstractList | OCT4 is a master regulator of self-renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We have examined the expression pattern of these OCT4 isoforms in various human pluripotent and nonpluripotent cells. Our data revealed that whereas OCT4A expression is restricted to embryonic stem (ES) and embryonal carcinoma (EC) cells, OCT4B can be detected in various nonpluripotent cell types. Furthermore, we detected a novel OCT4 spliced variant, designated OCT4B1, that is expressed primarily in human ES and EC cells and is downregulated following their differentiation. We also found a significantly higher level of OCT4B1 expression in stage-specific embryonic antigen-3 (SSEA3)(+) compared with SSEA3(-) subpopulations of cultured ES cells. Taken together, our data demonstrated a distinctive expression pattern for OCT4 spliced variants in different cell types and highlight the necessity of defining the type of OCT4 when addressing the expression of this gene in different human cells. OCT4 is a master regulator of self-renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We have examined the expression pattern of these OCT4 isoforms in various human pluripotent and nonpluripotent cells. Our data revealed that whereas OCT4A expression is restricted to embryonic stem (ES) and embryonal carcinoma (EC) cells, OCT4B can be detected in various nonpluripotent cell types. Furthermore, we detected a novel OCT4 spliced variant, designated OCT4B1, that is expressed primarily in human ES and EC cells and is downregulated following their differentiation. We also found a significantly higher level of OCT4B1 expression in stage-specific embryonic antigen-3 (SSEA3)(+) compared with SSEA3(-) subpopulations of cultured ES cells. Taken together, our data demonstrated a distinctive expression pattern for OCT4 spliced variants in different cell types and highlight the necessity of defining the type of OCT4 when addressing the expression of this gene in different human cells. Disclosure of potential conflicts of interest is found at the end of this article. OCT4 is a master regulator of self‐renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We have examined the expression pattern of these OCT4 isoforms in various human pluripotent and nonpluripotent cells. Our data revealed that whereas OCT4A expression is restricted to embryonic stem (ES) and embryonal carcinoma (EC) cells, OCT4B can be detected in various nonpluripotent cell types. Furthermore, we detected a novel OCT4 spliced variant, designated OCT4B1, that is expressed primarily in human ES and EC cells and is downregulated following their differentiation. We also found a significantly higher level of OCT4B1 expression in stage‐specific embryonic antigen‐3 (SSEA3)(+) compared with SSEA3(−) subpopulations of cultured ES cells. Taken together, our data demonstrated a distinctive expression pattern for OCT4 spliced variants in different cell types and highlight the necessity of defining the type of OCT4 when addressing the expression of this gene in different human cells. Disclosure of potential conflicts of interest is found at the end of this article. Abstract OCT4 is a master regulator of self-renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We have examined the expression pattern of these OCT4 isoforms in various human pluripotent and nonpluripotent cells. Our data revealed that whereas OCT4A expression is restricted to embryonic stem (ES) and embryonal carcinoma (EC) cells, OCT4B can be detected in various nonpluripotent cell types. Furthermore, we detected a novel OCT4 spliced variant, designated OCT4B1, that is expressed primarily in human ES and EC cells and is downregulated following their differentiation. We also found a significantly higher level of OCT4B1 expression in stage-specific embryonic antigen-3 (SSEA3)(+) compared with SSEA3(−) subpopulations of cultured ES cells. Taken together, our data demonstrated a distinctive expression pattern for OCT4 spliced variants in different cell types and highlight the necessity of defining the type of OCT4 when addressing the expression of this gene in different human cells. Disclosure of potential conflicts of interest is found at the end of this article. |
| Author | Mowla, Seyed J. Atlasi, Yaser Andrews, Peter W. Gokhale, Paul J. Ziaee, Seyed A.M. |
| Author_xml | – sequence: 1 givenname: Yaser surname: Atlasi fullname: Atlasi, Yaser – sequence: 2 givenname: Seyed J. surname: Mowla fullname: Mowla, Seyed J. email: sjmowla@modares.ac.ir – sequence: 3 givenname: Seyed A.M. surname: Ziaee fullname: Ziaee, Seyed A.M. – sequence: 4 givenname: Paul J. surname: Gokhale fullname: Gokhale, Paul J. – sequence: 5 givenname: Peter W. surname: Andrews fullname: Andrews, Peter W. email: p.w.andrews@sheffield.ac.uk |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18787205$$D View this record in MEDLINE/PubMed |
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| Snippet | OCT4 is a master regulator of self‐renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We have... OCT4 is a master regulator of self-renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We have... Abstract OCT4 is a master regulator of self-renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We... |
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| SubjectTerms | Alternative Splicing Antigens, Tumor-Associated, Carbohydrate - biosynthesis Cancer Cell Differentiation Cell Line, Tumor Embryonic stem cells Embryonic Stem Cells - cytology Exons Gene Expression Regulation HeLa Cells Humans Introns K562 Cells OCT4 OCT4B1 Octamer Transcription Factor-3 - biosynthesis Octamer Transcription Factor-3 - genetics Pluripotent Stem Cells - metabolism Protein Isoforms Spliced variants Stage-Specific Embryonic Antigens - biosynthesis Stem Cells - metabolism |
| Title | OCT4 Spliced Variants Are Differentially Expressed in Human Pluripotent and Nonpluripotent Cells |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1634%2Fstemcells.2008-0530 https://www.ncbi.nlm.nih.gov/pubmed/18787205 https://search.proquest.com/docview/1540222523 https://search.proquest.com/docview/69908720 |
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